7-Dehydrocholesterol - Wikipedia
网页7-Dehydrocholesterol (7-DHC) is a zoosterol that functions in the serum as a cholesterol precursor, and is photochemically converted to vitamin D 3 in the skin, therefore functioning as provitamin-D 3.
7-Dehydrocholesterol dictates ferroptosis sensitivity | Nature
网页2024年1月31日 — Nature - 7-Dehydrocholesterol (7-DHC) is a natural anti-ferroptotic metabolite and pharmacological manipulation of 7-DHC levels shows promise as a therapeutic strategy for cancer and...
Vitamin D: Production, Metabolism and Mechanisms of Action
网页2021年12月31日 — The precursor of vitamin D, 7-dehydrocholesterol (7-DHC) is on the Kandutsch-Russell cholesterol pathway. The final enzymatic reaction mediated by 7-dehyrocholesterol reductase converting 7-DHC to cholesterol is regulated by a number of factors including vitamin D and cholesterol which enhance its degradation thus enabling increased levels of 7 ...
7-脱氢胆固醇 - 维基百科，自由的百科全书
网页7-脱氢胆固醇（英語： 7-Dehydrocholesterol ，缩写7-DHC）是一种胆固醇合成的前体 [1] [2] ，同时也是维生素D 3 （胆钙化醇）合成的中间产物，会在光照下开环转化为维生素D 3 。
7 Dehydrocholesterol - an overview | ScienceDirect Topics
网页The DHCR-7 gene encodes the enzyme 7-dehydrocholesterol reductase which converts 7-dehydrocholesterol to cholesterol. 7-dehydrocholesterol is also the precursor to vitamin D produced via UVB exposure. High levels of 7-dehydrocholesterol reductase may results in low vitamin D levels as 7-dehydrocholesterol is preferentially converted to cholesterol.
7-Dehydrocholesterol: A sterol shield against an iron sword - Cell …
网页2024年4月4日 — Li et al. and Freitas et al. recently identified 7-dehydrocholesterol (7-DHC), a sterol produced through the cholesterol biosynthetic pathway, as a lipid-soluble antioxidant that protects cells from ferroptosis, a cell death pathway triggered by iron-catalyzed phospholipid peroxidation.
7-Dehydrocholesterol is an endogenous suppressor of ferroptosis
网页2024年1月31日 — The present study uncovered and characterized a role for 7-dehydrocholesterol reductase (DHCR7) in the ferroptotic process. DHCR7 catalyses the final step in cholesterol biosynthesis and its ...
New aspects of vitamin D metabolism and action - Nature
网页2020年2月6日 — The Kandutsch–Russell pathway is an alternative pathway to the Bloch pathway for cholesterol synthesis that directs zymosterol to 7-DHC, which can be converted by UVB radiation to vitamin D...
Vitamin D and Its Role in the Lipid Metabolism and the …
网页2021年2月9日 — Cholecalciferol, the form of vitamin D named D 3, is synthetized in the skin from 7-dehydrocholesterol upon irradiation with ultraviolet waves in the range of ultraviolet B light (UV-B) (Figure 1) . 7-dehydrocholesterol is part of the metabolic pathway that controls the synthesis of cholesterol in human cells. By absorbing ultraviolet radiation ...
7-Dehydrocholesterol | C27H44O | CID 439423 - PubChem
网页7-Dehydrocholesterol | C27H44O | CID 439423 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.