Regulation of stem and progenitor cells in the adrenal cortex
网页High plasticity of the adrenal gland is supported by pools of stem and progenitor cells that are deployed to sustain physiological and homeostatic demands. In recent decades, exciting new discoveries elucidating the identity, function, and fate …
Adrenal cortex renewal in health and disease - Nature
网页2021年5月19日 · Hyperactivation of stem cell activity or steroidogenesis and ectopic proliferation can all lead to tumorigenesis in the adrenal cortex in mice. Large-scale genomic analyses have identified ...
Stem cell function and plasticity in the normal physiology of the ...
网页2021年1月1日 · The adrenal cortex employs multiple cell populations with stem cell function to support cellular renewal. The outer mesenchymal capsule contains distinct populations of multipotent stem cells, including GLI+ and WT1+ cells, which are capable of giving rise to steroidogenic cells.
Regulation of the adrenocortical stem cell niche: implications for ...
网页2014年10月7日 · In this Review, we discuss the current knowledge on the establishment and maintenance of adrenocortical stem and progenitor cells. We first discuss basic adrenal biology and detail evidence for...
Stem cells, evolutionary aspects and pathology of the adrenal medulla ...
网页2020年12月1日 · In this review, we are summarizing the latest findings regarding stem cells in the adrenal medulla during development and adulthood, the co-dependency of the adrenal cortex and medulla with an evolutionary perspective and …
Embryonic Development and Adult Regeneration of the Adrenal …
网页2020年12月31日 · Here, we introduce the developmental processes of the adrenal gland and discuss current knowledge regarding stem/progenitor cells that regulate adrenal cortex remodeling and regeneration. This review will provide insights into the fascinating ongoing research on the development and regeneration of the adrenal cortex.
Molecular Mechanisms of Stem/Progenitor Cell Maintenance in the Adrenal …
网页2017年3月22日 · The three main classes of adrenal steroid hormones, mineralocorticoids, glucocorticoids, and androgens, are produced by the adrenal cortex under the tight regulation of distinct and independent endocrine regulatory loops: the renin–angiotensin–aldosterone system (RAAS) and the hypothalamus–pituitary–adrenal (HPA) …
Cell signaling pathways in the adrenal cortex: Links to stem
网页2017年4月15日 · The adrenal cortex is a dynamic tissue responsible for the synthesis of steroid hormones, including mineralocorticoids, glucocorticoids, and androgens in humans. Advances have been made in understanding the role of adrenocortical stem/progenitor cell populations in cortex homeostasis and self-renewa ….
Regulation of stem and progenitor cells in the adrenal cortex
网页The adrenal cortex is an endocrine organ comprised of three histological zones, the outermost zona glomerulosa, the intermediate zona fasciculata, and the innermost zona reticularis. High plasticity of the adrenal gland is supported by pools of stem and progenitor cells that are deployed to sustain …
Adrenocortical stem and progenitor cells: Implications for ...
网页2012年3月31日 · A population of stem/progenitor cells centripetally repopulates the adrenal cortex. Recent data suggest a dual fetal and capsular origin of the adult adrenal cortex. Stem/progenitor cell fate is regulated in part by Wnt-activated Dax1 and inhibin-α. Activated β-catenin and elevated IGF2 are implicated in adrenal tumorigenesis. Stem/pro...