Biological Activity of Berberine—A Summary Update - PMC
网页2020年11月12日 — Berberine was found to reverse doxorubicin resistance in MCF-7 and (ADR)-resistant MCF-7 breast cancer cells by inhibiting autophagy, which makes it a promising agent for clinical application in breast cancer treatment.
Berberine as a potential autophagy modulator - Wiley Online …
网页2019年2月15日 — In the present review, we discuss the effect of berberine on diverse cellular pathways and describe how berberine acts as an autophagy modulator to adjust physiologic and pathologic conditions and diminishes drug resistance in cancer therapy.
Berberine: A Promising Treatment for Neurodegenerative Diseases
网页2022年5月20日 — Studies have found that berberine can effectively alleviate the motor dysfunction of HTT mice and prolong their survival time, further studies proves that berberine promote the degradation of mutant HTT protein through enhancing autophagy function, thereby reducing the accumulation of mutant …
The Anti-Cancer Mechanisms of Berberine: A Review
网页2020年1月30日 — BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related …
Berberine induces autophagy in glioblastoma by targeting the
网页2016年10月11日 — Previous studies have shown that berberine (BBR), a natural plant alkaloid, has potent anti-tumor activity. However, the mechanisms leading to cancer cell death have not been clearly elucidated. In this study, we show that BBR has profound effects on the metabolic state of GBM cells, leading to high autophagy flux and impaired glycolytic capacity.
Berberine as a potential autophagy modulator - PubMed
网页In the present review, we discuss the effect of berberine on diverse cellular pathways and describe how berberine acts as an autophagy modulator to adjust physiologic and pathologic conditions and diminishes drug resistance in cancer therapy.
Berberine induces autophagic cell death and mitochondrial ... - PubMed
网页2010年12月15日 — Extensive studies have revealed that berberine, a small molecule derived from Coptidis rhizoma (Huanglian in Chinese) and many other plants, has strong anti-tumor properties. To better understand berberine-induced cell death and its underlying mechanisms in cancer, we examined autophagy and apoptosi …
Berberine-sonodynamic therapy induces autophagy and lipid …
网页2017年1月19日 — In the present study, berberine-mediated sonodynamic therapy (BBR-SDT) was used to induce autophagy and cholesterol efflux in THP-1 macrophages and derived foam cells.
Berberine represses human gastric cancer cell growth in vitro and …
网页2020年8月1日 — Inhibition of autophagy by 3-MA, CQ, Baf-A1 and BECN1 siRNA obviously increased cell viability of berberine-exposed gastric cancer cells, which confirmed the anti-cancer role of autophagy induced by berberine. Mechanistic studies showed that berberine inhibited mTOR, Akt and MAPK (ERK, JNK …
Berberine: An Important Emphasis on Its Anticancer Effects …
网页2022年9月10日 — Berberine reveals anticancer potential by directing cell signaling pathways, such as angiogenesis, cell cycle, apoptosis, autophagy, transcription factors, and other cell signaling molecules. In vitro-based studies indicate the efficacy and synergistic effect of berberine in disease management in combination with cancer agents or …
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