The short-term effects of berberine in the liver: Narrow margins ...
网页2022年9月1日 · Berberine is a plant alkaloid to which antihyperglycemic properties have been attributed. It is also known as an inhibitor of mitochondrial functions. In this work short-term translation of the latter effects on hepatic metabolism were investigated using the isolated perfused rat liver. Once-through ….
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · Our study demonstrates that berberine exerts a dual effect on insulin sensitivity and liver function, effectively mitigating insulin resistance while significantly enhancing hepatic function by alleviating inflammation.
Update on Berberine in Nonalcoholic Fatty Liver Disease
网页2013年6月17日 · Berberine (BBR), an active ingredient from nature plants, has demonstrated multiple biological activities and pharmacological effects in a series of metabolic diseases including nonalcoholic fatty liver disease (NAFLD). The recent literature points out that BBR may be a potential drug for NAFLD in …
Berberine in Non-Alcoholic Fatty Liver Disease—A Review
网页2022年8月23日 · The ameliorative NAFLD effect of BBR is likely linked to its favorable location in the liver and its direct impact on different hepatic genes involved in energy metabolism . Moreover, the half-life of BBR in hepatic tissue lasts longer than in other tissues, which shows why the liver is the main target organ of BBR [ 9 , 36 ].
Therapeutic Effects of Berberine on Liver Fibrosis are associated …
网页2022年3月2日 · In this review, we discuss the effects of BBR on liver fibrosis and lipid metabolism, particularly the metabolism of arachidonic acid, and highlight the potential mechanisms by which BBR relieves liver fibrosis through lipid metabolism related and intestinal flora related pathways.
The short-term effects of berberine in the liver: Narrow margins ...
网页2022年9月1日 · Berberine decreases gluconeogenesis and increases glycolysis in the perfused liver. • Berberine impairs hepatic ammonia detoxification. • Berberine diminishes liver ATP content and increases NADH/NAD+ ratio. • Effects are a consequence of impairment on mitochondrial respiration and pyruvate carboxylation. •
Molecular updates on berberine in liver diseases: Bench to bedside
网页BBR has been shown to modulate multiple signaling pathways implicated in the pathogenesis of liver diseases including Akt/FoxO2, PPAR-γ, Nrf2, insulin, AMPK, mTOR, and epigenetic pathways. In the present review, we have emphasized the important pharmacological activities and mechanisms of BBR in liver diseases.
Therapeutic Effects of Berberine on Liver Fibrosis are ... - PubMed
网页2022年3月2日 · Therapeutic Effects of Berberine on Liver Fibrosis are associated With Lipid Metabolism and Intestinal Flora. Front Pharmacol. 2022 Mar 2;13:814871. doi: 10.3389/fphar.2022.814871. eCollection 2022. Authors. Xianzhi Liu 1 2 3 , Lifu Wang 4 , Siwei Tan 1 2 3 , Zebin Chen 5 , Bin Wu 1 2 3 , Xiaoying Wu 1 2 3. Affiliations.
A phase 2, proof of concept, randomised controlled trial of berberine …
网页2021年9月17日 · Thus, subjects receiving 1000 mg twice a day of berberine ursodeoxycholate had significantly greater reduction in liver fat content than in placebo recipients (mean absolute decrease −4.8% vs....
Berberine alleviates liver fibrosis through inducing ferrous redox …
网页2021年12月4日 · Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis. Jiazhi Yi, Shuyun Wu, Siwei Tan, Yunfei Qin, Xing Wang,...