Effects of Berberine and Its Derivatives on Cancer: A Systems ...
网页2020年1月15日 — In addition to extensive biological activities, such as anti-inflammation, antioxidative, and anti-diabetic, berberine demonstrates anti-tumor activity by means of interference in tumorigenesis and in multiple features of tumor development.
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing ...
网页2019年12月31日 — The inhibitory effect of berberine on liver cancer cells was analyzed by CCK-8 and EdU assay. The glutamine concentrations were detected by ELISA and UHPLC-MRM-MS analysis. Glutamine metabolism-related proteins were determined by Western blot, immunofluorescent analysis and immunohistochemistry.
Berberine as a Potential Anticancer Agent: A Comprehensive …
网页2021年12月4日 — The therapeutic efficacy of BBR has been reported in several studies regarding colon, breast, pancreatic, liver, oral, bone, cutaneous, prostate, intestine, and thyroid cancers. BBR prevents cancer cell proliferation by inducing apoptosis and controlling the cell cycle as well as autophagy.
Berberine Protects against Hepatocellular Carcinoma Progression …
网页2024年8月13日 — Accumulating evidence suggests that berberine (BBR) exhibits anti-cancer effects in hepatocellular carcinoma (HCC). However, the mechanisms by which BBR regulates the immunological microenvironment in HCC has not been fully elucidated. In this study, a mouse model of orthotopic HCC is established and treated with varying doses of …
Berberine, a natural plant alkaloid, synergistically sensitizes human ...
网页To the best of our knowledge, this is the first study to demonstrate that berberine sensitized liver cancer cells to sorafenib treatment. These results suggest that berberine combined with sorafenib is able to inhibit the proliferation of liver cancer cells and induce apoptosis, which provides evidence for further clinical investigation in HCC ...
Unlocking the potential of Berberine: Advancing cancer therapy …
网页2024年8月10日 — Moreover, another study showed that BBR promoted autophagy in liver cancer cells by increasing glucose-regulated protein 78 (GRP78) gene expression [153]. BBR also enhanced the radiosensitivity of hepatocellular carcinoma (HCC) cells by downregulating the expression of nuclear factor erythroid 2–related factor 2 (Nrf2) [ 154 ].
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing ...
网页2019年12月31日 — The upregulation of SLC1A5 led to an increased glutamine uptake and improved tolerance to berberine. Berberine suppresses SLC1A5 expression by inhibiting c-Myc. Furthermore, berberine suppresses the growth of tumor xenografts, and the expression of SLC1A5 and c-Myc in vivo.
Berberine enhances the anti-hepatocellular carcinoma effect of …
网页2022年9月1日 — Berberine is one of the most promising clinically tested natural alkaloids, and immunotherapy using natural killer (NK) cells is a potentially effective treatment for hepatocellular carcinoma (HCC). This study aims to elucidate the effect of berberine on the anti-HCC effect of NK92-MI cells. Materials and methods.
Effects of Berberine on Liver Cancer - Yiting Liu, Ebuka …
网页2022年5月26日 — The multiple attributes of BBR involving effective inhibitory and cytotoxic actions against the proliferation of cancer cells have been demonstrated. The use of BBR in experimental studies (in vivo and in vitro) for over a decade for liver cancer treatment has proven to be highly effective, safe, and potent.
The pharmacological activity of berberine, a review for liver ...
网页2021年1月5日 — In vivo and in vitro evaluation showed that the preparation of berberine into fluorescent self-carried microrods was used for liver cancer efficiently and safely (Zheng et al., 2018). Liposomes had good potential as carriers of berberine because of the characteristics of uniform form and stable storage as well as slow-release effect.