Berberine: A Review of its Pharmacokinetics Properties and …
网页2021年11月3日 · Owing to its strong antioxidative and anti-inflammatory activities, oral administration of berberine (200 mg/kg) conferred cardioprotective effects in rats by improving post-MI/R cardiac function recovery and reducing infarct size after MI/R injury; the mechanism of action was found to be associated with the …
Effects and mechanisms of berberine in diabetes treatment
网页2012年8月1日 · Berberine from Rhizoma Coptidis is an oral hypoglycemic agent with anti-dyslipidemia and anti-obesity activities. Its metabolic activity of regulating blood glucose and lipids has been widely studied and evidenced in patients and various animal models. Berberine is known as an AMP-activated protein kinase (AMPK) activator.
Biological Activity of Berberine—A Summary Update - PMC
网页2020年11月12日 · Berberine is a plant metabolite belonging to the group of isoquinoline alkaloids with strong biological and pharmacological activity. Currently, berberine is receiving considerable interest due to its anticancer activity based on many biochemical pathways, especially its proapoptotic and anti-inflammatory activity.
Berberine, a natural alkaloid: Advances in its pharmacological …
网页2024年8月20日 · The review then delves into the specific mechanisms of action of berberine in each autoimmune disease, emphasizing its potential therapeutic benefits. In rheumatoid arthritis, berberine's effects on fibroblast-like synovial cells, dendritic cells, and CD4 + T cells are discussed, highlighting its potential to mitigate synovial inflammation and ...
The Anti-Cancer Mechanisms of Berberine: A Review
网页2020年1月30日 · Berberine (BBR) has been extensively studied in vivo and vitro experiments. BBR inhibits cell proliferation by regulating cell cycle and cell autophagy, and promoting cell apoptosis. BBR also inhibits cell invasion and metastasis by suppressing EMT and down-regulating the expression of metastasis-related proteins and signaling pathways.
Inhibition of inflammation by berberine: Molecular mechanism …
网页2024年6月1日 · In the realm of medicine, berberine finds extensive application in treating various inflammatory diseases, such as rheumatism and arthritis. This study encapsulates the nexus between berberine and inflammation, utilizing network pharmacology to preliminarily explore berberine's mechanisms in treating common inflammatory conditions.
Biological properties and clinical applications of berberine
网页This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive, metabolic, cardiovascular, and neurological diseases. Keywords: Coptis chinensis; berberine; clinical applications; mechanism; pharmacological properties. Publication types. Review. MeSH terms. Berberine* / pharmacology. Berberis*
Berberine as a therapy for type 2 diabetes and its ... - PubMed
网页In the present review, the anti-diabetic mechanism of berberine, its effect on diabetes-related complications, and its recent use in human clinical studies is highlighted. In addition, we summarize the different treatments for type 2 diabetes in adults and children.
Therapeutic Effects of Berberine in Metabolic Diseases and …
网页2021年5月27日 · Various mechanisms have been identified through which berberine might exert its effects, such as modulating AMP—activated kinase activity, protein kinase B phosphorylation, Janus kinase/signal transducers and activators of transcription modulation, and glycogen synthase kinase 3β modulation (Chang et al. 2016a, b).
Pharmacokinetics and Pharmacological Activities of Berberine in ...
网页2021年8月23日 · Berberine (BBR) is isolated as the main component in many TCM kinds (e.g., Rhizoma Coptidis and Berberidis Cortex). Furthermore, BBR can reduce blood sugar and blood fat, alleviate inflammation, and improve the state of patients.