Update on Berberine in Nonalcoholic Fatty Liver Disease
网页2013年6月17日 · Berberine (BBR), an active ingredient from nature plants, has demonstrated multiple biological activities and pharmacological effects in a series of metabolic diseases including nonalcoholic fatty liver disease (NAFLD). The recent literature points out that BBR may be a potential drug for NAFLD in …
Berberine in Non-Alcoholic Fatty Liver Disease—A Review
网页2022年8月23日 · BBR can penetrate the blood-brain barrier, and its metabolites are widely distributed in the liver, muscle, kidney, lung, heart, brain, pancreas, and adipose tissue. The organ distribution of BBR is fast, with maximum allocation in …
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical evidence remains inconclusive. This meta-analysis was conducted to assess the efficacy and safety of berberine for treating NAFLD.
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical evidence remains inconclusive. This meta-analysis was conducted to assess the efficacy and …
Berberine alleviates nonalcoholic fatty liver induced by a high …
网页Berberine (BBR) shows promising effects in the treatment of nonalcoholic fatty liver disease (NAFLD) by influencing various metabolic aspects. Inhibition of mitochondrial β-oxidation (β-OX) participates in the pathogenesis of NAFLD.
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver ...
网页2015年8月7日 · Animal experiments showed that BBR located favorably in the liver and altered hepatic metabolism-related gene expression. Conclusion: BBR ameliorates NAFLD and related metabolic disorders. The therapeutic effect of BBR on NAFLD may involve a direct regulation of hepatic lipid metabolism.
A phase 2, proof of concept, randomised controlled trial of berberine …
网页2021年9月17日 · Thus, subjects receiving 1000 mg twice a day of berberine ursodeoxycholate had significantly greater reduction in liver fat content than in placebo recipients (mean absolute decrease −4.8% vs....
Anti-inflammatory activity of berberine in non-alcoholic fatty liver ...
网页2020年5月19日 · Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. Recent studies have shown that the Angptl2 pathway mediated hepatic inflammatory response plays an important role in the progression of nonalcoholic fatty liver disease.
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver
网页2015年8月7日 · Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease. Hong-Mei Yan , Ming-Feng Xia , Yan Wang, Xin-Xia Chang, Xiu-Zhong Yao, Sheng-Xiang Rao, Meng-Su Zeng, Yin-Fang Tu, Ru Feng, Wei-Ping Jia, Jun Liu, Wei Deng, Jian-Dong Jiang , Xin Gao. Published: August 7, 2015. https://doi.org/10.1371/journal.pone.0134172. Article. Authors.
Berberine improves glucogenesis and lipid metabolism in …
网页2017年2月28日 · Nonalcoholic fatty liver disease (NAFLD) is considered a critical hepatic manifestation of metabolic syndrome. Berberine (BBR) exerts anti-hyperglycemic and anti-dyslipidemic effects and can also ameliorate NAFLD. Thus, BBR might exert its therapeutic effect on NAFLD by improving glucolipid metabolism.