Update on Berberine in Nonalcoholic Fatty Liver Disease
网页2013年6月17日 · Berberine (BBR), an active ingredient from nature plants, has demonstrated multiple biological activities and pharmacological effects in a series of metabolic diseases including nonalcoholic fatty liver disease (NAFLD). The recent literature points out that BBR may be a potential drug for NAFLD in …
Berberine - LiverTox - NCBI Bookshelf - National Center for ...
网页2020年10月6日 · Berberine has not been linked to serum aminotransferase elevations during therapy nor to instances of clinically apparent liver injury.
Berberine in Non-Alcoholic Fatty Liver Disease—A Review
网页2022年8月23日 · BBR can penetrate the blood-brain barrier, and its metabolites are widely distributed in the liver, muscle, kidney, lung, heart, brain, pancreas, and adipose tissue. The organ distribution of BBR is fast, with maximum allocation in …
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical evidence remains inconclusive. This meta-analysis was conducted to assess the efficacy and safety of berberine for treating NAFLD.
The short-term effects of berberine in the liver: Narrow margins ...
网页2022年9月1日 · Berberine is a plant alkaloid to which antihyperglycemic properties have been attributed. It is also known as an inhibitor of mitochondrial functions. In this work short-term translation of the latter effects on hepatic metabolism were investigated using the isolated perfused rat liver. Once-through ….
Molecular updates on berberine in liver diseases: Bench to bedside
网页BBR has been shown to modulate multiple signaling pathways implicated in the pathogenesis of liver diseases including Akt/FoxO2, PPAR-γ, Nrf2, insulin, AMPK, mTOR, and epigenetic pathways. In the present review, we have emphasized the important pharmacological activities and mechanisms of BBR in liver diseases.
The short-term effects of berberine in the liver: Narrow margins ...
网页2022年9月1日 · Berberine decreases gluconeogenesis and increases glycolysis in the perfused liver. • Berberine impairs hepatic ammonia detoxification. • Berberine diminishes liver ATP content and increases NADH/NAD+ ratio. • Effects are a consequence of impairment on mitochondrial respiration and pyruvate carboxylation. •
Berberine alleviates nonalcoholic fatty liver induced by a high …
网页Berberine (BBR) shows promising effects in the treatment of nonalcoholic fatty liver disease (NAFLD) by influencing various metabolic aspects. Inhibition of mitochondrial β-oxidation (β-OX) participates in the pathogenesis of NAFLD.
Berberine improves glucogenesis and lipid metabolism in …
网页2017年2月28日 · 67 Citations. 10 Altmetric. Metrics. Abstract. Background. Nonalcoholic fatty liver disease (NAFLD) is considered a critical hepatic manifestation of metabolic syndrome. Berberine (BBR) exerts anti-hyperglycemic and anti-dyslipidemic effects and can also ameliorate NAFLD.
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver
网页2015年8月7日 · With its preferential distribution in liver, BBR profoundly ameliorated liver steatosis in the NAFLD patients from our randomized clinical trial and directly regulated the expression of hepatic genes related to glucose and lipid-metabolism.