The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical evidence remains inconclusive. This meta-analysis was conducted to assess the efficacy and safety of berberine for treating NAFLD.
Berberine in Non-Alcoholic Fatty Liver Disease—A Review
网页2022年8月23日 · The intestinal microbiota and bacterial metabolites may play a role in the development of liver diseases through different mechanisms, usually connected with intestinal permeability triggering the release of lipopolysaccharide (LPS), cytokines, and gut microbiota DNA into the system circulation and to the liver, accelerating inflammation ...
Update on Berberine in Nonalcoholic Fatty Liver Disease
网页2013年6月17日 · Berberine (BBR), an active ingredient from nature plants, has demonstrated multiple biological activities and pharmacological effects in a series of metabolic diseases including nonalcoholic fatty liver disease (NAFLD). The recent literature points out that BBR may be a potential drug for NAFLD in …
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical evidence remains inconclusive. This meta-analysis was conducted to assess the efficacy and …
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · The primary outcomes comprised liver function markers such as glutamyl transpeptidase (GGT), alanine transaminase (ALT), aspartate transaminase (AST), lipid indices including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol …
Molecular updates on berberine in liver diseases: Bench to bedside
网页BBR has been shown to modulate multiple signaling pathways implicated in the pathogenesis of liver diseases including Akt/FoxO2, PPAR-γ, Nrf2, insulin, AMPK, mTOR, and epigenetic pathways. In the present review, we have emphasized the important pharmacological activities and mechanisms of BBR in liver diseases.
Berberine in Non-Alcoholic Fatty Liver Disease-A Review
网页2022年8月23日 · One of the most promising is Berberine (BBR). Its pleiotropic effect positively impacts various cardiometabolic aspects. In this review, we summarize NAFLD, its metabolic and cardiovascular complications, the hepatoprotective effects of BBR due to its broad spectrum of pharmacological effects, and the potential role of BBR in NAFLD therapy.
The short-term effects of berberine in the liver: Narrow margins ...
网页2022年9月1日 · Berberine decreases gluconeogenesis and increases glycolysis in the perfused liver. •. Berberine impairs hepatic ammonia detoxification. •. Berberine diminishes liver ATP content and increases NADH/NAD+ ratio. •. Effects are a consequence of impairment on mitochondrial respiration and pyruvate carboxylation. •.
A phase 2, proof of concept, randomised controlled trial of …
网页2021年9月17日 · Thus, subjects receiving 1000 mg twice a day of berberine ursodeoxycholate had significantly greater reduction in liver fat content than in placebo recipients (mean absolute decrease −4.8% vs....
A Descriptive Review of the Antioxidant Effects and Mechanisms of ...
网页3 天之前 · liver disease (NAFLD) and alcohol-related liver disorders. This review aims to highlight the distinct mechanisms by which berberine and silymarin exert their antioxidant effects.
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