Update on Berberine in Nonalcoholic Fatty Liver Disease
网页2013年6月17日 · Berberine (BBR), an active ingredient from nature plants, has demonstrated multiple biological activities and pharmacological effects in a series of metabolic diseases including nonalcoholic fatty liver disease (NAFLD). The recent literature points out that BBR may be a potential drug for NAFLD in …
Berberine in Non-Alcoholic Fatty Liver Disease—A Review
网页2022年8月23日 · One of the most promising is Berberine (BBR). Its pleiotropic effect positively impacts various cardiometabolic aspects. In this review, we summarize NAFLD, its metabolic and cardiovascular complications, the hepatoprotective effects of BBR due to its broad spectrum of pharmacological effects, and the potential role of BBR in NAFLD therapy.
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · This study evaluated the efficacy and safety of berberine, a natural compound, for treating non-alcoholic fatty liver disease (NAFLD). It included 10 randomized controlled trials (RCTs) and found that berberine significantly improved liver function, lipid profiles and insulin resistance in NAFLD patients.
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · This meta-analysis demonstrates berberine's efficacy in improving liver enzymes, lipid profile, and insulin sensitivity in NAFLD patients. These results indicate that berberine shows promise as an adjunct therapy for NAFLD.
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · In animal studies, the administration of berberine has the potential to enhance Sirtuin 1 expression, facilitate the deacetylation and stability of carnitine palmitoyl transferase 1A protein, and enhance liver fatty acid oxidation, thereby ameliorating NAFLD .
Berberine alleviates nonalcoholic fatty liver induced by a high-fat ...
网页Berberine (BBR) shows promising effects in the treatment of nonalcoholic fatty liver disease (NAFLD) by influencing various metabolic aspects. Inhibition of mitochondrial β-oxidation (β-OX) participates in the pathogenesis of NAFLD.
Berberine in Non-Alcoholic Fatty Liver Disease-A Review
网页2022年8月23日 · One of the most promising is Berberine (BBR). Its pleiotropic effect positively impacts various cardiometabolic aspects. In this review, we summarize NAFLD, its metabolic and cardiovascular complications, the hepatoprotective effects of BBR due to its broad spectrum of pharmacological effects, and the potential role of BBR in NAFLD therapy.
A phase 2, proof of concept, randomised controlled trial of …
网页2021年9月17日 · Here the authors report an 18-week phase 2, randomised, double-blind, placebo-controlled clinical trial that tested the effect of berberine ursodeoxycholate in patients with fatty liver...
Berberine improves glucogenesis and lipid metabolism in …
网页2017年2月28日 · Nonalcoholic fatty liver disease (NAFLD) is considered a critical hepatic manifestation of metabolic syndrome. Berberine (BBR) exerts anti-hyperglycemic and anti-dyslipidemic effects and can also ameliorate NAFLD. Thus, BBR might exert its therapeutic effect on NAFLD by improving glucolipid metabolism.
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver
网页2015年8月7日 · With its preferential distribution in liver, BBR profoundly ameliorated liver steatosis in the NAFLD patients from our randomized clinical trial and directly regulated the expression of hepatic genes related to glucose and lipid-metabolism.
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