Update on Berberine in Nonalcoholic Fatty Liver Disease
网页2013年6月17日 · Berberine (BBR), an active ingredient from nature plants, has demonstrated multiple biological activities and pharmacological effects in a series of metabolic diseases including nonalcoholic fatty liver disease (NAFLD). The recent literature points out that BBR may be a potential drug for NAFLD in …
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · Non-alcoholic fatty liver disease (NAFLD) is becoming increasingly prevalent worldwide, emerging as a significant health issue on a global scale. Berberine exhibits potential for treating NAFLD, but clinical evidence remains inconclusive. This meta-analysis was conducted to assess the efficacy and safety of berberine for treating NAFLD.
Berberine in Non-Alcoholic Fatty Liver Disease—A Review
网页2022年8月23日 · One of the most promising is Berberine (BBR). Its pleiotropic effect positively impacts various cardiometabolic aspects. In this review, we summarize NAFLD, its metabolic and cardiovascular complications, the hepatoprotective effects of BBR due to its broad spectrum of pharmacological effects, and the potential role of BBR in NAFLD therapy.
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 · Importantly, Berberine exhibited a favorable safety profile, with only mild gastrointestinal adverse events reported. Conclusion: This meta-analysis demonstrates berberine's efficacy in improving liver enzymes, lipid profile, and insulin sensitivity in NAFLD patients.
The Therapeutic Effect of Berberine in the Treatment of …
网页2016年7月3日 · According to analysis result, berberine has positive efficacy on blood lipids, blood glucose, liver function, insulin resistance, and fatty liver condition of NAFLD patients. However, due to the limitation of number and quality of trials included, more clinical randomized controlled trials with high quality are needed for further verification ...
The pharmacological activity of berberine, a review for liver ...
网页2021年1月5日 · In recent years, the protective effect of berberine on liver has been explored extensively with complex mechanisms reported. The paper summarized its pharmacological activities in liver protection to provide updated information on pharmacology and comprehensive references for scientific research and clinical application.
The short-term effects of berberine in the liver: Narrow margins ...
网页2022年9月1日 · Berberine decreases gluconeogenesis and increases glycolysis in the perfused liver. •. Berberine impairs hepatic ammonia detoxification. •. Berberine diminishes liver ATP content and increases NADH/NAD+ ratio. •. Effects are a consequence of impairment on mitochondrial respiration and pyruvate carboxylation. •.
A phase 2, proof of concept, randomised controlled trial of berberine …
网页2021年9月17日 · Thus, subjects receiving 1000 mg twice a day of berberine ursodeoxycholate had significantly greater reduction in liver fat content than in placebo recipients (mean absolute decrease −4.8% vs....
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver ...
网页2015年8月7日 · PMCID: PMC4529214. DOI: 10.1371/journal.pone.0134172. Abstract. Objectives: A randomized, parallel controlled, open-label clinical trial was conducted to evaluate the effect of a botanic compound berberine (BBR) on NAFLD.
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver
网页2015年8月7日 · A total of 184 eligible patients with NAFLD were enrolled and randomly received (i) lifestyle intervention (LSI), (ii) LSI plus pioglitazone (PGZ) 15mg qd, and (iii) LSI plus BBR 0.5g tid, respectively, for 16 weeks.
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