Cytotoxic CD8 + T cells in cancer and cancer immunotherapy
网页2020年9月15日 · Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.
CD8 + T cells maintain killing of MHC-I-negative tumor cells …
网页2023年8月3日 · The accepted paradigm for both cellular and anti-tumor immunity relies upon tumor cell killing by CD8 + T cells recognizing cognate antigens presented in the context of target cell major...
CD8 T-cell subsets: heterogeneity, functions, and therapeutic …
网页2023年11月1日 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector...
The Roles of CD8 + T Cell Subsets in Antitumor Immunity - PubMed
网页These subsets, referred to as the Tc subsets, have also been detected in tumor microenvironments (TMEs), where they potentially influence the antitumor response and patient outcomes. In this review, we highlight the prevalence and roles of …
CD8 + cytotoxic T lymphocytes in cancer immunotherapy: A review - PubMed
网页Cancer-associated fibroblasts (CAFs), macrophage type 2 (M2) cells, and regulatory T cells (Tregs) could make immunologic barriers against CD8 + T cell-mediated antitumor immune responses. Thus, CD8 + T cells are needed to be primed and activated toward effector CTLs in a process called tumor immunity cycle for making durable and efficient ...
CD8+ T cells in the cancer-immunity cycle - ScienceDirect
网页2023年10月10日 · CD8 + T cells are end effectors of cancer immunity. Most forms of effective cancer immunotherapy involve CD8 + T cell effector function. Here, we review the current understanding of T cell function in cancer, …
CD8 + T cells in the cancer-immunity cycle - Cell Press
网页CD4 + T cells can have pro- or anti-tumor effects, including providing “help” for CD8 + T cells, influencing myeloid and other cells within the TME, and mediating either direct cytotoxicity or regulatory effects.
Circadian tumor infiltration and function of CD8 - Cell Press
网页Additionally, anti-PD-1 treatment at ZT13 also increased the production of interferon (IFN)γ and Granzyme B in tumor-infiltrating CD8 + T cells compared with ZT1 (Figure 5 G). To maximize the observed chrono-therapeutic anti-tumor effects, we combined timed OT-I T cell therapy with timed anti-PD-1 infusion.
Tumor-infiltrating CD8+ T cell antitumor efficacy and exhaustion ...
网页CD8 + T cells are one of the primary tumor-infiltrating immune cells that deliver antitumor responses. Here, we review the influence of various factors in the TME on CD8 + T cell exhaustion and survival, and possible strategies for restoring CD8 + T cell effector function through immunotherapy.
The Roles of CD8 + T Cell Subsets in Antitumor Immunity - Cell …
网页2020年7月2日 · As typical cytotoxic CD8 + T cells, Tc1s demonstrate exceptional cytotoxic activity and efficiently kill tumor cells and cells harboring intracellular pathogens. Induction of Tc1s is mediated by the cytokine IL-12 [ 4 ], typically produced by antigen-presenting cells (APCs), including macrophages and dendritic cells, upon exposure to pathogen ...