Update on Berberine in Nonalcoholic Fatty Liver Disease
网页2013年6月17日 — Berberine (BBR), an active ingredient from nature plants, has demonstrated multiple biological activities and pharmacological effects in a series of metabolic diseases including nonalcoholic fatty liver disease (NAFLD). The recent literature points out that BBR may be a potential drug for NAFLD in …
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 — Berberine can modulate the physiological axis connecting the gut and the liver, leading to a balanced composition of intestinal microbes, maintenance of intestinal integrity, and reduction in enterogenic endotoxins entering the liver. As a result, this multifaceted influence contributes to effectively reducing liver …
Berberine – A Powerful Supplement With Many Benefits - Healthline
网页2023年6月13日 — Fatty liver: It may reduce fat buildup in the liver, which could theoretically help protect against NAFLD . Heart failure: One older study showed that it improved symptoms and reduced the...
Berberine in Non-Alcoholic Fatty Liver Disease—A Review
网页2022年8月23日 — BBR can penetrate the blood-brain barrier, and its metabolites are widely distributed in the liver, muscle, kidney, lung, heart, brain, pancreas, and adipose tissue. The organ distribution of BBR is fast, with maximum allocation in the liver and a minor distribution in fat [36].
Berberine: Benefits, supplements, side effects, dosage, and more
网页2023年10月20日 — According to 2014 research, berberine shows promise as a potential diabetes treatment, especially for those who cannot take existing anti-diabetic drugs due to heart disease, liver failure, or...
Therapeutic Effects of Berberine on Liver Fibrosis are associated …
网页2022年3月2日 — Animal experiments demonstrated that the pre-administration of BBR can reduce triglyceride accumulation in the liver caused by tunicamycin administration, thus treating liver injury. In particular, compared with the control group, the BBR group downregulated lipid metabolism-related gene expression of stearoyl-Coenzyme A desaturase 1 (SCD1).
Molecular updates on berberine in liver diseases: Bench to bedside
网页BBR has been shown to modulate multiple signaling pathways implicated in the pathogenesis of liver diseases including Akt/FoxO2, PPAR-γ, Nrf2, insulin, AMPK, mTOR, and epigenetic pathways. In the present review, we have emphasized the important pharmacological activities and mechanisms of BBR in liver diseases.
Berberine in Non-Alcoholic Fatty Liver Disease-A Review
网页2022年8月23日 — One of the most promising is Berberine (BBR). Its pleiotropic effect positively impacts various cardiometabolic aspects. In this review, we summarize NAFLD, its metabolic and cardiovascular complications, the hepatoprotective effects of BBR due to its broad spectrum of pharmacological effects, and the potential role of BBR in NAFLD therapy.
The short-term effects of berberine in the liver: Narrow margins ...
网页2022年9月1日 — Berberine decreases gluconeogenesis and increases glycolysis in the perfused liver. •. Berberine impairs hepatic ammonia detoxification. •. Berberine diminishes liver ATP content and increases NADH/NAD+ ratio. •. Effects are a consequence of impairment on mitochondrial respiration and pyruvate carboxylation. •.
The pharmacological activity of berberine, a review for liver ...
网页2021年1月5日 — The hepatoprotective effect of berberine has been extensively studied, so we comprehensively summarize the pharmacological activities of lipid metabolism regulation, bile acid adjustment, anti-inflammation, oxidation resistance, anti-fibrosis and anti-cancer and so on.