Estrogen - Wikipedia
网页Estrogen (British English: oestrogen; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. [1][2] There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). ...
Estrogen | Hormone Balance, Menopause & PMS | Britannica
网页2024年8月16日 · estrogen, any of a group of hormones that primarily influence the female reproductive tract in its development, maturation, and function. There are three major hormones—estradiol, estrone, and estriol—among the estrogens, and estradiol is the predominant one.
Estrogen - StatPearls - NCBI Bookshelf
网页2023年6月26日 · Estrogen is a steroid hormone associated with the female reproductive organs and is responsible for developing female sexual characteristics. Estrogen or estradiol is the most common form of estrogen hormone for FDA-approved treatment as hormone replacement therapy (HRT) in managing symptoms associated with menopause.
Estradiol | C18H24O2 | CID 5757 - PubChem
网页Estradiol workings by binding to subtypes of the estrogen receptor: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). It also exerts potent agonism of G Protein-coupled estrogen receptor (GPER), which is recognized an important regulator of …
History of Estrogen: Its Purification, Structure, Synthesis, Biologic ...
网页2018年12月18日 · Sophisticated biochemical methods revealed the mechanisms of estrogen synthesis through the enzyme aromatase and, after discovery of the estrogen receptors, their specific biologic actions. Molecular techniques facilitated understanding of the specific transcriptional and translational events requiring estrogen.
Estrogen Hormone Biology - PMC - National Center for …
网页Estrogen works through its two distinct nuclear receptors, Estrogen Receptor alpha (ERα) and Estrogen Receptor beta (ERβ). Various transcriptional regulation mechanisms have been identified as the mode of action for estrogen, mainly the classical mechanism with direct DNA binding but also a non-genomic mode of action and one using tethered or ...
Production and Actions of Estrogens | New England Journal of …
网页2002年1月31日 · Estrogens have widespread biologic actions, and there are naturally occurring phytoestrogens that mimic some of the actions of endogenously produced estrogens. In this review, we will focus on new...
The structural biology of oestrogen metabolism - PMC
网页The three most common estrogens are estrone (E1), estradiol (E2) and estriol (E3). A fourth oestrogen is estetrol (E4). Estradiol is the most potent. Estrone and estradiol are synthesised by the aromatisation of androstenedione and testosterone, respectively (Fig. 1).
Molecular biology and physiology of estrogen action - UpToDate
网页2023年9月29日 · The key components are the C or DNA-binding domain, which binds with high affinity and specificity to DNA sequences (estrogen response elements [EREs]) to regulate transcription rates of target genes, and the E or ligand-binding domain, which binds estrogens and estrogen analogues.
Estrogen Hormone Biology - PubMed
网页Abstract. The hormone estrogen is involved in both female and male reproduction, as well as numerous other biological systems including the neuroendocrine, vascular, skeletal, and immune systems.