The Genetics of Pituitary Adenomas - PMC - National Center for ...
网页2019年12月21日 · The genetic landscape of pituitary adenomas (PAs) is diverse and many of the identified cases remain of unclear pathogenetic mechanism. Germline genetic defects account for a small percentage of all patients and may present in the context of relevant family history.
The Genetics of Pituitary Adenomas - PubMed
网页2019年12月21日 · The genetic landscape of pituitary adenomas (PAs) is diverse and many of the identified cases remain of unclear pathogenetic mechanism. Germline genetic defects account for a small percentage of all patients and may present in the context of relevant family history.
Genetic and Epigenetic Causes of Pituitary Adenomas
网页2021年1月26日 · To obtain a comprehensive understanding of the molecular biological characteristics of different types of PAs, we reviewed the important advances that have been made involving genetic and epigenetic variation, comprising genetic mutations, chromosome number variations, DNA methylation, microRNA regulation, and transcription factor regulation.
HEREDITARY PITUITARY TUMOR SYNDROMES: GENETIC AND CLINICAL ASPECTS
网页In this review, we summarize the clinical and pathophysiological aspects of the different hereditary pituitary tumor syndromes. Keywords: Carney complex; Multiple endocrine neoplasia; Oncogene; Pituitary adenoma; Tumor suppressor gene.
Genetic and Epigenetic Causes of Pituitary Adenomas
网页2021年1月26日 · To obtain a comprehensive understanding of the molecular biological characteristics of different types of PAs, we reviewed the important advances that have been made involving genetic and epigenetic variation, comprising genetic mutations, chromosome number variations, DNA methylation, microRNA regulation, and transcription factor regulation.
The clinical aspects of pituitary tumour genetics - PMC
网页2021年2月4日 · Pituitary tumours can occur in a familial setting, either isolated [Familial Isolated Pituitary Adenoma (FIPA), for example aryl hydrocarbon receptor-interacting protein (AIP) mutation-positive FIPA, or in patients with X-linked acrogigantism (XLAG)], or as part of a syndromic condition, such as MEN1 or MEN4, Carney complex (CNC), McCune ...
Consensus guideline for the diagnosis and management of pituitary ...
网页2024年2月9日 · Germline genetic abnormalities in CYP with GH-secreting pituitary adenomas have been identified in patients with familial isolated pituitary adenoma (AIP, GPR101 (female predominance,...
Consensus guideline for the diagnosis and management of pituitary ...
网页2024年2月9日 · Compared with adult patients with pituitary adenomas, we highlight that, in the CYP group, there is a greater proportion of functioning tumours, including macroprolactinomas, greater likelihood...
Pituitary adenomas: new insights, new therapeutic targets
网页2023年1月2日 · Several factors have hindered previous efforts at elucidating the pathogenesis of pituitary adenomas, including the small size of many of these tumors, possible admixture of tumor cells...
The genetics of pituitary adenomas - ScienceDirect
网页2010年6月1日 · The clinical entity of familial isolated pituitary adenomas (FIPA) is characterized by genetic defects in the aryl hydrocarbon receptor interacting protein ( AIP) gene in about 15% of all kindreds and 50% of homogenous somatotropinoma families.
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