Recent advances in understanding the role of IL-4 signaling
网页2021年9月7日 · IL-4 induces elevated cell surface expression of CD23 (the low-affinity IgE receptor) on B cells and of class II major histocompatibility complex (MHC) molecules. In addition, IL-4 acts as a T-cell growth factor in both humans and mice and promotes the differentiation of Th2 cells.
Recent advances in understanding the role of IL-4 signaling
网页2021年9月7日 · Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target cells spanning the innate and adaptive immune systems a ….
An IL-4 signalling axis in bone marrow drives pro-tumorigenic ...
网页2023年12月6日 · Our study defines a central role for IL-4 in controlling immunosuppressive myelopoiesis in cancer, identifies a novel combination therapy for immune checkpoint blockade in humans, and highlights...
Evolution and function of interleukin-4 receptor signaling in …
网页2020年3月6日 · The cytokines interleukin (IL)-4 and IL-13, signaling via the IL-4 receptor (IL-4R), orchestrate type 2 immunity to helminth infections and toxins.
Interleukin-4 receptor signaling and its binding mechanism: A ...
网页2016年12月1日 · This review article discusses the structure, function and pathway of IL-4 and IL-4Rα, and their role in allergic, malignant and viral diseases. It also covers the design and development of various inhibitors to block IL-4/IL-4Rα interaction, such as mutant analogs, antibodies and immunotoxins.
Interleukin-4: A Cytokine to Remember - PMC - National Center …
网页2012年11月1日 · IL-4 signaling. IL-4 is a cytokine that functions as a potent regulator of immunity secreted primarily by mast cells, Th2 cells, eosinophils and basophils.
Interleukin-4 receptor signaling modulates neuronal network …
网页2022年6月6日 · We discovered a major role for the interleukin-4 (IL-4)/IL-4 receptor alpha (IL-4Rα) signaling pathway in synaptic processes, as indicated by transcriptome analysis in IL-4Rα–deficient mice and human neurons with/without IL-4 treatment.
The IL-4 receptor: signaling mechanisms and biologic functions
网页Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4R alpha chain and the common gamma chain (gamma c), resulting in a series of phosphorylation ….
THE IL-4 RECEPTOR: Signaling Mechanisms and Biologic Functions
网页Here we describe our current understanding of the organization of the IL-4 receptor, of the signaling pathways that are induced as a result of receptor occupancy, and of the various mechanisms through which receptor function is modulated.
Untangling the Complex Web of IL-4– and IL-13–Mediated Signaling …
网页A study now proposes a potential molecular mechanism to explain the functional differences between IL-4 and IL-13 that involves the ability of IL-4, but not IL-13, to effectively activate the insulin receptor substrate–2 (IRS-2) signaling cascade through binding to its receptor.
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