Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation …
网页2020年11月3日 — The implications of direct LXR-mediated actions and regulation of cholesterol metabolism in the control of inflammatory diseases and cancer progression. This table summarizes the different experimental models …
Integrating the roles of liver X receptors in inflammation and ...
网页2020年8月1日 — Liver X receptors (LXRs) are transcription factors from the nuclear receptor family that can be pharmacologically activated by high-affinity agonists. LXR activation exerts a combination of metabolic and anti-inflammatory actions that result in the modulation of immune responses and in the amelioration of inflammatory disorders.
Liver X receptors in lipid signalling and membrane homeostasis
网页2018年6月14日 — Liver X receptors (LXRs) are ligand-activated nuclear receptors that modulate lipid homeostasis. Cellular and systemic cholesterol homeostasis is maintained by LXRs...
The roles of liver X receptor α in inflammation and inflammation ...
网页This review gives an overview of the recent advances in understanding the roles of LXRα in inflammation and inflammation-associated diseases, which will help in the design of future experimental researches on the potential of LXRα and advance the investigation of LXRα as pharmacological inflammatory targets.
Liver X Receptors in Atherosclerosis and Inflammation
网页2011年4月15日 — The peroxisome proliferator-activated receptor (PPAR)γ and liver X receptor (LXR) nuclear receptors play important roles in both lipid metabolism and inflammation. 1 The endogenous agonists for PPARγ and LXR are fatty acids 2 and oxysterols, 3 respectively, and there is a large body of literature that has established both of these receptors ...
Lipid metabolism extinguishes cGAS–STING-induced inflammation
网页2023年11月3日 — Liver X receptor (LXR) signalling can inhibit the DNA-sensing cGAS–STING inflammatory pathway through degradation of the second messenger cGAMP.
Liver X Receptors Link Lipid Metabolism and Inflammation
网页In immune cells, particularly in macrophages, LXRs also inhibit pro-inflammatory gene expression. This Review will highlight recent studies that connect LXR-dependent control of lipid metabolism to regulation of the immune response. Keywords: Metabolism, Inflammation, Lipids, Cholesterol, Transcription, Nuclear Receptors. Go to: Introduction.
The Challenges and Promise of Targeting the Liver X Receptors …
网页The LXRs, like other nuclear receptors, are anti-inflammatory, inhibiting signal-dependent induction of pro-inflammatory genes by nuclear factor-κB, activating protein-1, and other transcription factors. Synthetic LXR agonists have been shown to ameliorate atherosclerosis and a wide range of inflammatory disorders in preclinical animal models.
Liver X receptors link lipid metabolism and inflammation
网页2017年5月27日 — The Liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that regulate gene networks controlling cholesterol and lipid metabolism. In immune cells, particularly in macrophages, LXRs also inhibit proinflammatory gene expression.
LXRs link metabolism to inflammation through Abca1 …
网页This led us to explore additional mechanisms for LXR inflammatory crosstalk. We found that an LXR L439A/E441A mutant that lacks co-activator recruitment capacity was unable to …