Putative Repurposing of Lamivudine, a Nucleoside/Nucleotide …
网页2021年7月21日 · Lamivudine, also widely known as 3TC belongs to a family of nucleotide/nucleoside analogues of cytidine or cytosine that inhibits the Reverse Transcriptase (RT) of retroviruses such as HIV.
Twenty-Five Years of Lamivudine: Current and Future Use for the ...
网页2018年6月1日 · Lamivudine (2′-deoxy-3′-thiacytidine, 3TC) is a first-generation nucleoside reverse transcriptase inhibitor (NRTI) that was approved for the treatment of HIV-1 infection in 1995 and hepatitis B virus (HBV) infection in 1998. 1,2 Lamivudine has been evaluated in more than 50 clinical studies registered on ClinicalTrials.gov involving >25,000 ...
Lamivudine protects mice from gastric ulcer by activating PGK1 to ...
网页2024年9月1日 · It has been reported that the perturbations in the equilibrium between reactive oxygen species (ROS) generation and the ability to neutralize reactive intermediates efficiently result in oxidative stress which contributes to various gastrointestinal diseases including gastric ulcer [58].
Lamivudine - PubMed
网页2024年2月28日 · Lamivudine, a nucleoside reverse transcriptase inhibitor (NRTI), is a cornerstone in the therapeutic landscape for managing HIV-1 and hepatitis B infections. This comprehensive activity explores the diverse indications and contraindications for lamivudine across both conditions, elucidating its mech ….
Lamivudine - StatPearls - NCBI Bookshelf
网页2024年2月28日 · Lamivudine is used in combination with 2 or more antivirals to prevent rapid mutations that can lead to drug resistance in HIV-1 patients, specifically via the M184V reverse transcriptase single substitution mutation that has shown to occur in as little as 8 weeks of mono- or combination antiviral therapy that contains lamivudine (3TC).
Comparison of Sequential Three-Drug Regimens as Initial Therapy …
网页2003年12月11日 · This multicenter, randomized, partially double-blind trial used a factorial design to compare pairs of sequential three-drug regimens, starting with a regimen including zidovudine and lamivudine...
Nucleoside reverse transcriptase inhibitors and Kamuvudines inhibit ...
网页2021年4月14日 · Two classes of small molecule inflammasome inhibitors—nucleoside reverse transcriptase inhibitors (NRTIs) and their antiretrovirally inert modified analog Kamuvudines—both inhibit AβOs-induced RPE...
网页permeability data of lamivudine as well as its therapeutic index, its pharmacokinetic proper-ties, data indicating excipient interactions, and reported BE/bioavailability (BA) studies were taken into consideration. Lamivudine is highly soluble, but its permeability characteristics are not well-defined.
Lamivudine: Uses, Interactions, Mechanism of Action - DrugBank …
网页A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Discover how groundbreaking research is turning "undruggable" targets into therapeutic opportunities.
Efficacy and safety of switching to dolutegravir plus lamivudine …
网页Our findings show the efficacy and safety of dolutegravir plus lamivudine as a simplified therapy switch option for selected people with HIV with virological suppression on triple ART.
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