Acid-degradable lipid nanoparticles enhance the delivery of …
网页2024年8月23日 · Acid-degradable lipids composed of polyethylene glycol lipids, anionic lipids and cationic lipids were synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly...
Adjuvant lipidoid-substituted lipid nanoparticles augment the ...
网页2023年6月26日 · A lipid nanoparticle (LNP) component—an adjuvant lipidoid—is developed to enhance the adjuvanticity of LNPs, which significantly increases the innate and adaptive responses of the...
Lipid nanoparticles with PEG-variant surface modifications mediate ...
网页2023年10月13日 · We generated LNP variants through the inclusion of positively charged-amine-modified polyethylene glycol (PEG)-lipids (LNPa), negatively charged-carboxyl-(LNPz) and carboxy-ester (LNPx) modified...
The role of lipid components in lipid nanoparticles for vaccines …
网页2022年9月1日 · Lipid nanoparticles (LNPs) play an important role in mRNA vaccines against COVID-19. In addition, many preclinical and clinical studies, including the siRNA-LNP product, Onpattro®, highlight that LNPs unlock the …
Optimized lipid nanoparticles (LNPs) for organ-selective nucleic …
网页2024年4月23日 · In this section, we summarize organ-targeted LNPs developed for nucleic acid delivery and discuss specific targeting strategies, providing readers with a contemporary overview of the development of targeted LNPs.
Lipid Nanoparticle Spherical Nucleic Acids for Intracellular …
网页2021年8月11日 · Lipid nanoparticle SNAs (LNP-SNAs) have been synthesized for the delivery of DNA and RNA to targets in the cytoplasm of cells. Both the composition of the LNP core and surface-presented DNA sequences contribute to LNP-SNA activity. G-rich sequences enhance the activity of LNP-SNAs compared to T-rich ….
网页2023年1月6日 · The formulation mechanism of lipid nanocarriers and the structural phase transitions occurring upon encapsu- lation of nucleic acids have been previously investigated by synchrotron small-angle X-ray scattering (SAXS)19,20and the component distributions across the LNP by SANS.21,22.
Efficient mRNA delivery using lipid nanoparticles modified with ...
网页2023年9月29日 · Of various nonviral nucleic acid delivery systems, lipid nanoparticles (LNPs) are the most advanced, but still, are very inefficient as the majority are unable to escape from endosomes/lysosomes. Here, we develop a highly efficient gene delivery system using fusogenic coiled-coil peptides.
Lipid nanoparticles for delivery of RNA therapeutics: Current status ...
网页2022年10月24日 · Lipid nanoparticles (LNPs) have been one of the most successful nano-delivery vehicles that enable efficient delivery of cytotoxic chemotherapy agents, antibiotics, and nucleic acid therapeutics.
Recent Advances in the Lipid Nanoparticle-Mediated Delivery of …
网页2023年3月14日 · Lipid nanoparticles (LNPs) have recently emerged as one of the most advanced technologies for the highly efficient in vivo delivery of exogenous mRNA, particularly for COVID-19 vaccine delivery. LNPs comprise four different lipids: ionizable lipids, helper or neutral lipids, cholesterol, and lipids attached to polyethylene glycol (PEG).
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