Tumor associated mast cells: biological roles and therapeutic ...
网页2020年9月9日 · Role of Mast Cells in Tumor Growth. MCs appear to be able to promote tumor development through many different ways: they could facilitate tumor angiogenesis through heparin-like molecules and heparin could further permit neovascularisation and metastases through its anti-clotting effects.
Mast Cell Tumors - American College of Veterinary Surgeons
网页Mast cell tumors are the most common type of skin tumor found in dogs and the second most common skin tumor in cats. These represent 14–21% of all skin tumors diagnosed in dogs. They are usually noticed in middle aged patients, but can occur in patients of any age. Boxers and Boston terriers make up ~ 50% of all cases.
Mastocytoma - Wikipedia
网页A mastocytoma or mast cell tumor is a type of round-cell tumor consisting of mast cells. It is found in humans and many animal species; it also can refer to an accumulation or nodule of mast cells that resembles a tumor.
Mast Cells: A New Frontier for Cancer Immunotherapy - PMC
网页2021年5月21日 · Mast cells are orchestrators of anti-tumor immunity and tumor control. Mast cells directly impact tumor cells as well as immune and non-immune components of the tumor microenvironment through chemokine secretion and release of other mediators, leading to varied cancer-promoting or …
Canine mast cell tumors: diagnosis, treatment, and prognosis
网页2014年8月12日 · Mast cell tumors (MCTs) are the most common malignant skin cancer in dogs, and significant variability exists in their biological behavior. Most MCTs are cured with appropriate local therapy, but a subset shows malignant behavior with the potential to spread to lymph nodes, liver, spleen, and other areas …
How to evaluate the patient with a suspected mast cell disorder …
网页2022年12月9日 · Mast cell activation syndromes (MCASs) represent a heterogeneous group of disorders characterized by (1) the episodic presence of mast cell activation symptoms in more than 2 organ systems, such as cutaneous, cardiovascular, GI, pulmonary, and naso-ocular; (2) response of symptoms to mast cell mediator–targeting drugs; and (3) the detection ...
Mast cell heparanase promotes breast cancer stem-like features …
网页1 天前 · At the limiting dose of 2.5×10 3 cells/mouse, a small difference was observed in tumor volumes with or without mast cells, but, at the end of the experiments, 70% of mice co-injected with mast ...
Mast Cells in the Tumor Microenvironment - PubMed
网页Mast cells play a multifaceted role in the tumor microenvironment by modulating various events of tumor biology, such as cell proliferation and survival, angiogenesis, invasiveness, and metastasis. Moreover, tumor-associated mast cells have the potential to shape the tumor microenvironment by establishing crosstalk with other tumor-infiltrating ...
Role of mast cells activation in the tumor immune …
网页2023年12月5日 · Firstly, we evaluated the infiltration density and location of mast cells on tumor progression. Secondly, mast cells are activated by the TME and subsequently release a range of inflammatory mediators, cytokines, chemokines, and lipid products that modulate their pro-or anti-tumor functions.
Focus on mast cells in the tumor microenvironment: Current …
网页2023年1月1日 · Mast cells (MCs) are crucial cells participating in both innate and adaptive immune processes that play important roles in protecting human health and in the pathophysiology of various diseases, such as allergies, cardiovascular diseases, and autoimmune diseases.