MYH10 Gene - GeneCards | MYH10 Protein | MYH10 Antibody
网页2024年8月6日 · MYH10 (Myosin Heavy Chain 10) is a Protein Coding gene. Diseases associated with MYH10 include Congenital Ptosis and Microphthalmia/Coloboma 12 . Among its related pathways are Semaphorin interactions and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases .
Heterozygous variants in MYH10 associated with …
网页2024年1月4日 · MYH10 knockout cells demonstrate defects in primary ciliogenesis and reduced ciliary length with impaired Hedgehog signaling. MYH10 variant overexpression produced a dominant-negative effect on ciliary length.
Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell …
网页2018年12月15日 · This study aimed to investigate the effects of the MYH10 gene on normal human glial cells and glioma cell lines in vitro, by gene silencing, and to determine the signaling pathways involved. Previous studies have shown that NM IIA and NM IIB can regulate cell movement by controlling cell polarization [ 19 ].
Myh10 deficiency leads to defective extracellular matrix ... - Nature
网页2018年11月2日 · Loss of Myh10 specifically in mesenchymal cells results in ECM deposition defects and alveolar simplification. Notably, MYH10 expression is downregulated in the lung of emphysema patients.
Heterozygous variants in MYH10 associated with …
网页2022年10月1日 · The pleiotropic effects of MYH10 may implicate alterations in a common set of signaling pathways. Our data show that MYH10 plays a role not only in primary ciliogenesis, but also in ciliary length control that is conserved between species and in cells of distinct developmental origin. 31, 32, 33 This effect on ciliary length is consistent with ...
Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell ... - PubMed
网页2018年12月15日 · This study aimed to investigate the effects of the MYH10 gene on normal human glial cells and glioma cell lines in vitro, by gene silencing, and to determine the signaling pathways involved. MATERIAL AND METHODS The normal human glial cell line HEB, and the glioma cell lines, U251, T98G, and SHG44 were studied.
MYH10 Governs Adipocyte Function and Adipogenesis through …
网页2022年2月21日 · This study establishes the importance of MYH10 in adipogenesis and adipocyte function, and more specifically, its interaction with GLUT4 and facilitation of translocation of GLUT4 to the cell membrane as part of the insulin signaling pathway. We initially identified changes in the distribution of MYH10 …
MYH10 activation rescues contractile defects in arrhythmogenic
网页2023年10月13日 · Our findings demonstrate that activation of MYH10 corrects the deleterious effect of PKP2 mutant over systolic cardiac contraction, with potential implications for ACM therapy.
(PDF) Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces …
网页2018年12月15日 · This study aimed to investigate the effects of the MYH10 gene on normal human glial cells and glioma cell lines in vitro, by gene silencing, and to determine the signaling pathways involved.
Heterozygous variants in MYH10 associated with …
网页MYH10 knockout cells showed defects in primary ciliogenesis and reduced ciliary length with impaired Hedgehog signaling. MYH10 variant overexpression produced a dominant-negative effect on ciliary length.