Oripavine - Wikipedia
网页Oripavine is an opioid and the major metabolite of thebaine. It is the parent compound from which a series of semi-synthetic opioids are derived, which includes the compounds etorphine and buprenorphine. Although its analgesic potency is comparable to morphine, it is not used clinically due to its severe toxicity and low therapeutic index. Due ...
Oripavine | C18H19NO3 | CID 5462306 - PubChem
网页Oripavine is a morphinane alkaloid with formula C18H19NO3. It is the major metabolite of thebaine. It has a role as an opioid analgesic and a bacterial xenobiotic metabolite. It is a morphinane alkaloid, an organic heteropentacyclic compound, a tertiary amino compound, an ether and an organic hydroxy compound.
Oripavine - an overview | ScienceDirect Topics
网页'Oripavine' is a phenolic compound found in Papaver orientate and P. bracteatum, which yields thebaine upon methylation with diazomethane. AI generated definition based on: The Isoquinoline Alkaloids, 1965
Oripavine - an overview | ScienceDirect Topics
网页Psychoactive morphinan alkaloids (morphine, codeine, thebaine, oripavine) are the predominant reason for its cultivation (Gupta, 2016). Many plants in Papaver species have minimal quantities of opium and of no commercial value.
Update of the Scientific Opinion on opium alkaloids in poppy seeds
网页2018年5月16日 · Oripavine possesses an analgesic potency comparable to morphine and much higher than that of thebaine; however, it is not clinically useful due to severe toxicity and low therapeutic index (WHO Advisory group, 1981).
Recent Advances in the Chemistry of Oripavine and Its Derivatives
网页2014年8月1日 · Oripavine is the major alkaloid of Papaver orientale. It is an important intermediate in the biosynthesis of morphine alkaloids. Recently, new Papaver somniferum strains have been developed which...
Oripavine - an overview | ScienceDirect Topics
网页2017年1月20日 · Opioids are a class of drugs that include opiates (e.g., opium, diamorphine, morphine, codeine, thebaine, and oripavine) and semi- and synthetic drugs (e.g., meperidine, pethidine, hydromorphone, methadone, hydrocodone, oxycodone, and fentanyl) that have similar actions to those of opiates (Volkow et al., 2011).
Oripavine as a new marker of opiate product use
网页2011年6月17日 · Oripavine was found to be a new and useful putative marker of opium/poppy seed use in differentiation from heroin, pharmaceutical codeine, and pharmaceutical morphine use. The presence of oripavine in the urine of opium users is probably the result of O -demethylation of the opium alkaloid thebaine.
网页2014年5月2日 · Oripavine is the major alkaloid of Papaver orientale. It is an important intermediate in the bio-synthesis of morphine alkaloids. Recently, new Papaver somniferum strains have been developed...
Buprenorphine: A Unique Drug with Complex Pharmacology
网页Buprenorphine, an oripavine derivative, is used clinically for pain management [21,74]. This opioid analgesic, which was the focus of many clinical trials for the treatment of opioid dependency [ 32 , 47 , 49 , 50 , 59 ], even in opiate addicts with a history of cocaine co-abuse [ 72 , 85 , 86 ], has recently been approved for the treatment of ...