Stem Cells as Target for Prostate cancer Therapy: Opportunities …
网页Cancer stem cells (CSCs) and cells in a cancer stem cell-like (CSCL) state have proven to be responsible for tumor initiation, growth, and relapse in Prostate Cancer (PCa) and other cancers; therefore, new strategies are being developed to …
Prostate Cancer Stem Cells: Clinical Aspects and Targeted …
网页2022年7月8日 · Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC. In this minireview, we discuss the impact of PCSCs in the ...
Prostate Stem Cells and Cancer Stem Cells - PMC - National …
网页Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both …
Targeting prostate cancer stem-like cells by an …
网页2020年3月17日 · Studies in prostate cancer show that prostate cancer stem-like cells (PCSCs) are isolated from various experimental and clinical sources of prostate cancer by various methods, including low-adhesion or suspension 3D-cultures based on their anchorage-independent growth feature and antibody-based fluorescence-activated cell sorting (FACS) based ...
Single-cell analysis of human primary prostate cancer reveals the ...
网页2022年1月10日 · To identify putative prostate cancer stem cells that may contribute to prostate cancer development, we used an adult stem cell signature gene set 38 and found that 56.4% of the BE...
Cancer stem cell in prostate cancer progression, metastasis and …
网页2023年5月1日 · Cancer stem cells (CSCs) have critical role in cancer progression and reoccurrence; hence they are considered as a promising therapeutic target for cancer therapy (Fig. 6). Several transcription factors including OCT4, KLF4, SOX2, MYC, Nanog, are well studied which regulate CSCs activities.
Prostate Cancer Stem Cells: Clinical Aspects and Targeted
网页2022年7月8日 · Despite decades of research and successful improvements in diagnosis and therapy, prostate cancer (PC) remains a major challenge. In recent years, it has become clear that PC stem cells (PCSCs) are the driving force in tumorigenesis, relapse, metastasis, and therapeutic resistance of PC.
Prostate Cancer Stem Cells: Biology and Treatment Implications
网页2023年10月4日 · Mutations in prostate stem cells can lead to the formation of prostate cancer. Prostate CSCs (PCSCs) have been identified and partially characterized. These express surface markers include CD44, CD133, integrin α2β1, and pluripotency factors like OCT4, NANOG, and SOX2.
Prostate cancer stem cells are a moving target, UCLA researchers …
网页2013年12月3日 · Following recent studies showing that prostate cancer originates in basal stem cells, UCLA researchers were surprised to discover that the cancer eventually begins to grow from a different type of cell called a luminal stem cell. The new discovery indicates that the basal stem cells evolve into luminal stem cells as the cancer grows.
Single-cell transcriptomics identifies a distinct luminal …
网页2020年8月17日 · The identification of prostate stem/progenitor cells and characterization of the prostate epithelial cell lineage hierarchy are critical for understanding prostate cancer initiation.