Quinine, an old anti-malarial drug in a modern world: role in the ...
网页2011年5月24日 · Quinine remains an important anti-malarial drug almost 400 years after its effectiveness was first documented. However, its continued use is challenged by its poor tolerability, poor compliance with complex dosing regimens, and the availability of more efficacious anti-malarial drugs.
Chloroquine - Wikipedia
网页Chloroquine is a medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects. [1] Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. [1]
Quinine - Wikipedia
网页Quinine is a medication used to treat malaria and babesiosis. [5] This includes the treatment of malaria due to Plasmodium falciparum that is resistant to chloroquine when artesunate is not available. [5] [6] While sometimes used for nocturnal leg cramps, quinine is not recommended for this purpose due to the risk of serious side effects. [5]
The host targeting effect of chloroquine in malaria - PMC
网页2020年8月18日 · Historically, the worldwide use of quinoline based-drugs has led to a spectacular reduction in death from malaria. Unfortunately, scientists have been forced to seek alternative drugs to treat malaria due to the emergence of chloroquine-resistant parasites in the 1960s.
Quinine and chloroquine - ScienceDirect
网页2016年3月1日 · Quinine and chloroquine poisoning are characterized by severe cardiovascular toxicity resulting from sodium and potassium channel blockade, leading to hypotension, shock, arrhythmias and cardiac arrest. Quinine poisoning can cause irreversible visual loss. Severity of symptoms is closely related to the ingested dose and plasma concentration.
Chloroquine and Quinine - SpringerLink
网页2014年11月3日 · Abstract. Chloroquine is used to prevent and treat malaria in limited geographical areas (e.g., Central America and the Far East) and to manage immunological disorders such as systemic lupus erythematosus and rheumatoid arthritis. It represents the most severe and frequent cause of poisoning by any antimalarial drug.
The past, present and future of anti-malarial medicines
网页2019年3月22日 · It is thought that the structurally related quinoline drugs (such as quinine, mepacrine, chloroquine and mefloquine) act through the disruption of haemoglobin digestion in the blood stage of the parasite . These drugs are commonly used in combination with a complementary drug (e.g. mefloquine and …
The antimalarial drugs quinine, chloroquine and mefloquine are ...
网页2007年5月14日 · For most of the last century drugs such as quinine, chloroquine and mefloquine (Lariam) have provided a safe, cheap and effective method of controlling malaria. The antimalarial properties of these compounds are thought to be a consequence of inhibiting parasite growth within infected erythrocytes (Bray et …
Quinine and chloroquine - ScienceDirect
网页2012年3月1日 · Since no specific therapeutic drugs for treating COVID‐19 have been approved by FDA, recent studies suggest that the known antimalarial quinine and its derivatives (chloroquine and hydroxychloroquine) inhibit receptor binding of the viral particles and inhibits the strong “cytokine storm”, which is …
Quinine and chloroquine - ScienceDirect
网页2012年3月1日 · Quinine and chloroquine are the most common antimalarial drugs encountered in acute poisoning. 1 Their severe toxicity in overdose results from cardiotoxicity secondary to Na +-channel blocking effects.
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