Retinoic acid receptor alpha - Wikipedia
网页Retinoic acid receptor-alpha, the protein, interacts with retinoic acid, a derivative of vitamin A, which plays an important role in cell growth, differentiation, and the formation of organs in embryonic development.
RARA Gene - GeneCards | RARA Protein | RARA Antibody
网页2024年8月6日 · RARA (Retinoic Acid Receptor Alpha) is a Protein Coding gene. Diseases associated with RARA include Acute Promyelocytic Leukemia and Hematologic Cancer. Among its related pathways are Gene expression (Transcription) and …
RARA gene - MedlinePlus
网页The RARA gene provides instructions for making a transcription factor called the retinoic acid receptor, alpha (RARα). A transcription factor is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes.
RARA fusion genes in acute promyelocytic leukemia: a review
网页RARA fusion proteins behave as potent transcriptional repressors of retinoic acid signalling, inducing a differentiation blockage at the promyelocyte stage which can be overcome with therapeutic doses of ATRA or arsenic trioxide. However, resistance to these two drugs is a major problem, which necessitates development of new therapies.
Single molecule tracking reveals functions for RarA at replication ...
网页2019年2月13日 · RarA is a widely conserved protein proposed to be involved in recombination-dependent replication. We present a cell biological approach to identify functional connections between RarA and...
UniProt
网页Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed: 28167758, PubMed: 37478846, PubMed: 21152046). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed ...
The rarA gene as part of an expanded RecFOR recombination ... - PLOS
网页2021年12月22日 · The RarA protein, homologous to human WRNIP1 and yeast MgsA, is a AAA + ATPase and one of the most highly conserved DNA repair proteins. With an apparent role in the repair of stalled or collapsed replication forks, the molecular function of this protein family remains obscure.
Multi-omics and machine learning reveal context-specific gene ...
网页2023年2月9日 · The PML::RARA fusion protein is the hallmark driver of Acute Promyelocytic Leukemia (APL) and disrupts retinoic acid signaling, leading to wide-scale gene expression changes and uncontrolled...
RARA retinoic acid receptor alpha [ Homo sapiens (human) ]
网页2024年8月27日 · The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes.
Unraveling the physiological roles of retinoic acid receptor …
网页2021年9月29日 · The RORα gene, which is located on human chromosome 15q22.2, generates by alternative splicing four human isoforms comprising a conserved DNA-binding domain (DBD), ligand-binding domain (LBD),...
跳至内容