Mastocytosis: Types, Symptoms & Treatment - Cleveland Clinic
网页Mastocytosis (pronounced “mas-to-sy-TOE-sis”) is a rare disease that happens when your body makes too many mast cells. Mast cells are white blood cells and part of your immune system. They go to work when intruders like bacteria and allergens threaten your body. Mast cells react to intruders by releasing histamine.
Systemic mastocytosis - Symptoms and causes - Mayo Clinic
网页2020年11月20日 · When you have systemic mastocytosis, excess mast cells build up in your skin, bone marrow, digestive tract or other body organs. When triggered, these mast cells release substances that can cause signs and symptoms similar to those of an allergic reaction and, sometimes, severe inflammation that may result in organ damage.
Systemic Mastocytosis: Radiological Point of View - PMC
网页2021年9月1日 · In systemic mastocytosis (SM), various organ systems, such as the lympho-reticular, respiratory, cardiovascular, gastrointestinal, and skeletal systems, may be involved, with a frequent localization in extracutaneous organs such as the liver spleen, lymph nodes, and gastrointestinal tract. 1 However, skeletal involvement is one of …
Mast Cells, Mastocytosis, and Related Disorders
网页2015年7月9日 · Aggressive systemic mastocytosis, which is characterized by specific tissue damage associated with mast cells, is most commonly identified in the bone marrow, liver,...
Systemic mastocytosis - Diagnosis and treatment - Mayo Clinic
网页2020年11月20日 · The five main types of systemic mastocytosis include: Indolent systemic mastocytosis. This is the most common type and usually doesn't include organ dysfunction. Skin symptoms are common, but other organs may be affected, and the disease may worsen slowly over time. Smoldering systemic mastocytosis.
Mastocytosis (cutaneous and systemic) in adults ... - UpToDate
网页2024年7月11日 · Mastocytosis describes a group of rare disorders in which there is pathologic accumulation of mast cells in tissues. These diseases can be limited to the skin (cutaneous mastocytosis [CM]) or involve extracutaneous …
Mastocytosis: 2016 updated WHO classification and novel …
网页2017年3月16日 · At the same time, the classification of mastocytosis and related diagnostic criteria have been refined and updated by the consensus group and the World Health Organization (WHO). As a result, more specific therapies tailored toward prognostic subgroups of patients have been developed.
Mast cells and mastocytosis | Blood - American Society of …
网页2008年8月15日 · It is now accepted that the majority of adults with mastocytosis have the D816V mutation if bone marrow mononuclear cells are examined. With time and disease severity, and in a subset of patients, the clone expands sufficiently to be detected in peripheral blood.
Mastocytosis: Symptoms, cause, treatment, and more - Medical News Today
网页2023年12月20日 · Mastocytosis is a rare disorder in which excessive numbers of mast cells gather in tissues in the body. Mast cells develop in the bone marrow,...
Systemic Mastocytosis - StatPearls - NCBI Bookshelf
网页2023年7月4日 · Systemic mastocytosis is an aggressive disorder characterized by the release of numerous vasoactive cell mediators due to excessive activity of mast cells, which results in a wide variety of symptoms. Symptoms include anaphylaxis, flushing, nonspecific GI as well as neuropsychiatric complaints.