Transcriptional and chromatin regulation in interferon and …
网页2018年12月1日 · Viral RNA recognition and IFN-JAK-STAT signaling drive cellular antiviral responses through gene expression-based immunity. IRF3, NFkB, and ISGF3 are the essential conductors of the dual phase antiviral transcriptional response program. Dynamic chromatin regulation governs both the production of and response to IFN.
Transcriptional Regulation of Antiviral Interferon-Stimulated …
网页2017年7月1日 · Understanding the different mechanisms of ISG transcription and how their modes of action relate to clinically used antiviral medications will provide new insights into virus–host interactions and novel avenues for antiviral drug development.
Decoding type I and III interferon signalling during viral infection
网页2019年4月1日 · The organelle-damaging effects of certain viral infections signal to the host cell that something is amiss, prompting the cell to trigger antiviral responses through IFN signalling.
Transcriptional co-activators: emerging roles in signaling …
网页2023年11月13日 · The interaction is mediated by TFIID subunits: the TATA-binding protein (TBP) and the TATA-binding protein associated factors (TAFs). 43 Numerous studies have documented that TAFs function as co...
TBK1-METTL3 axis facilitates antiviral immunity - Cell Press
网页2022年2月15日 · After recognizing the pathogen-associated molecular patterns (PAMPs) of viruses, PRRs trigger innate immune signaling and initiate the transcription of antiviral immune genes, including type I IFNs, which are the primary antiviral effectors.
PPM1A Regulates Antiviral Signaling by Antagonizing TBK1
网页2015年3月27日 · Here, we show that PPM1A negatively regulates antiviral signaling by targeting STING in its phosphatase activity-dependent manner, and in a line with this, PPM1A catalytically dephosphorylates STING and TBK1 in vitro. Importantly, we provide evidence that whereas TBK1 promotes STING aggregation in a phosphorylation-dependent manner, PPM1A ...
Regulation of antiviral innate immune signaling and viral evasion ...
网页2021年11月16日 · Recognition of viral nucleic acids by PRRs triggers transduction of downstream signals mainly via adaptor proteins such as mitochondrial antiviral signaling protein (MAVS) or stimulator of...
Regulation of IRF3 activation in human antiviral signaling pathways
网页2022年6月1日 · Cellular signaling upon virus detection recruits scaffold proteins NAP1, TBKBP1 and TANK to TBK1 for a competitive binding to the coiled-coil 2 (CC2) domain. Based on the induced signaling, alternative complexes, such as TBK1-NAP1, are formed to recruit TBK1 towards a certain subcellular location.
VANGL2 inhibits antiviral IFN-I signaling by targeting TBK1 for
网页2023年6月23日 · We identified VANGL2 as an important negative regulator of antiviral IFN-I signaling by strengthening the selective autophagic degradation of TBK1. The core component of PCP, VANGL2, represents an “innate immune brake” for antiviral immunity, which can potentially to be an immune checkpoint.
Microtubule disruption synergizes with STING signaling to show …
网页2024年2月26日 · The MMAE and cGAMP co-treatment enhances the TBK1-STING-IRF3 cascade, type I IFNs induction, and NF-kB immune response of the STING signaling. Importantly, the combination of MMAE and cGAMP triggers promising antiviral effect in vitro and in vivo in a STING-dependent manner.
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