Alternative tumour-specific antigens | Nature Reviews Cancer
网页2019年7月5日 · The study of tumour-specific antigens (TSAs) as targets for antitumour therapies has accelerated within the past decade. The most commonly studied class of TSAs are those derived from...
A Roadmap Toward the Definition of Actionable Tumor-Specific Antigens
网页2020年12月3日 · The search for tumor-specific antigens (TSAs) has considerably accelerated during the past decade due to the improvement of proteogenomic detection methods. This provides new opportunities for the development of novel antitumoral immunotherapies to mount an efficient T cell response against one or …
Tumor Antigens - Tumor Antigens - Merck Manual Professional Edition
网页Tumor-specific antigens (TSAs) are unique to tumor cells. TSAs and TAAs typically are portions of intracellular molecules expressed on the cell surface often associated with molecules encoded by the major histocompatibility …
Neoantigens: promising targets for cancer therapy
网页2023年1月6日 · Neoantigens are newly formed antigens generated by tumor cells as a result of various tumor-specific alterations, such as genomic mutation, dysregulated RNA splicing, disordered...
Antigen presentation in cancer: insights into tumour ... - Nature
网页2021年3月9日 · Tumour antigens are displayed on the surface of cells by class I human leukocyte antigens (HLA-I). To elicit an effective antitumour response, antigen presentation has to be successful at two...
Uncovering the Tumor Antigen Landscape: What to Know about …
网页2020年6月23日 · 2.2. Tumor-Specific Antigens. TSAs are a category of antigens restricted to tumors and are not found in healthy cells; this is the result of malignant mutations or the expression of viral elements. Neoantigens, oncoviral antigens, and endogenous retroviral elements belong to this category [30,35,93].
The Origin and Immune Recognition of Tumor-Specific Antigens
网页2020年9月12日 · The dominant paradigm holds that spontaneous and therapeutically induced anti-tumor responses are mediated mainly by CD8 T cells and directed against tumor-specific antigens (TSAs). The presence of specific TSAs on cancer cells can only be proven by mass spectrometry analyses.
Alternative tumour-specific antigens - PubMed
网页2020年7月5日 · The study of tumour-specific antigens (TSAs) as targets for antitumour therapies has accelerated within the past decade. The most commonly studied class of TSAs are those derived from non-synonymous single-nucleotide variants (SNVs), or …
Noncoding regions are the main source of targetable tumor-specific antigens
网页Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but few have been identified thus far. We therefore developed a proteogenomic approach to enable the high-throughput discovery of TSAs coded by potentially all genomic regions.
Tumor neoantigens: from basic research to clinical applications
网页2019年9月6日 · Tumor neoantigens are peptides that display on the tumor cell surface and could be recognized by neoantigen-specific T cells. They play a critical role in tumor-specific immunity and cancer immunotherapies. Learn about the historical overview, identification methods and clinical applications of tumor neoantigens.
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