YAP induces a neonatal-like pro-renewal niche in the adult heart
网页2024年2月14日 · In YAP5SA adult and control neonatal hearts, spatial co-localization and signaling interplay among the cellular triad are essential to induce a pro-renewal myocardial niche. The YAP-induced ...
Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP ...
网页2023年8月5日 · Adult cardiomyocyte proliferation can be triggered by overexpression of active yes associated protein 1 (YAP), a Hippo pathway effector that controls organ size 10, 11. In the neonatal heart,...
Cardiac-Specific YAP Activation Improves Cardiac Function and …
网页2014年5月15日 · Myocardial AAV9 with human YAP[S127A] expressed from the cardiac troponin T promoter (AAV9:hYAP) injection post–myocardial infarction (MI) improved cardiac function and mouse survival. A, Schematic of AAV9:hYAP therapeutic trial …
The Hippo pathway in the heart: pivotal roles in development, …
网页2018年8月15日 · The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily conserved pathway that controls organ size. Hippo signalling restrains cardiomyocyte proliferation during development to...
An updated review of YAP: A promising therapeutic target against ...
网页2024年1月1日 · The transcriptional co-activator Yes-associated protein (YAP) functions as a downstream effector of the Hippo signaling pathway and plays a crucial role in cardiomyocyte survival. In its non-phosphorylated activated state, YAP binds to transcription factors, activating the transcription of downstream target genes.
Cardiac-specific YAP activation improves cardiac function and …
网页2014年7月18日 · Using adeno-associated virus subtype 9 (AAV9) as a delivery vector, we expressed human YAP (hYAP) in the adult murine myocardium immediately after MI. We found that AAV9:hYAP significantly improved cardiac function and mouse survival. AAV9:hYAP did not exert its salutary effects by reducing cardiomyocyte apoptosis.
Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy …
网页Our data demonstrate that, in response to PO, YAP is activated in the myocardium through a RhoA-dependent mechanism. Haploinsufficiency of YAP in CMs led to attenuated hypertrophy, but increased fibrosis and apoptosis, and …
YAP Promotes Infarct Resolution by Stimulating Intercellular Signaling
网页2021年9月30日 · YAP (yes-associated protein) promotes myocardial regeneration through multiple mechanisms. Activation of YAP in cardiomyocytes in the post–myocardial infarction (MI) heart promotes proliferation and survival of cardiomyocytes, maintains mitochondrial quality, and stimulates fibrosis resolution, all …
YAP/TAZ as mechanobiological signaling pathway in …
网页YAP exerts a protective effect against ferroptosis, an intracellular iron-dependent form of cell death in myocardial I/R injury. Upregulation of YAP reduces iron-dependent cell death signals, thereby, ameliorating heart damage.
Microtubules Sequester Acetylated YAP in the Cytoplasm and …
网页2024年8月26日 · After myocardial infarction, YAP acetylation is increased, which promotes YAP cytoplasmic localization. Compared with controls, mice that were genetically engineered to express a K265R mutation that prevents YAP K256 acetylation showed improved cardiac regenerative ability and increased YAP nuclear localization.
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