TYK2: an emerging therapeutic target in rheumatic disease
网页2024年3月11日 · In this Review, we discuss the biology of TYK2, including similarities to and differences from JAK1, JAK2 and JAK3, and evaluate the currently known efficacy and safety data from TYK2...
Current understanding of the role of tyrosine kinase 2 signaling in ...
网页2022年1月1日 · Clinical studies on the therapeutic effects and the underlying mechanisms of Tyk2 inhibitors in autoimmune or chronic inflammatory diseases are currently ongoing. This review summarizes the findings of studies examining the role of Tyk2 in immune and/or inflammatory responses using Tyk2 -deficient cells and mice.
Kinase inhibition in autoimmunity and inflammation | Nature Reviews …
网页2020年10月19日 · This Review captures the current efforts, progress and new discoveries around kinase inhibitors with an emphasis on key clinically validated pathways and targets with potential to mitigate...
Allosteric TYK2 inhibition: redefining autoimmune disease therapy ...
网页2023年8月14日 · Summary. JAK inhibitors impact multiple cytokine pathways simultaneously, enabling high efficacy in treating complex diseases such as cancers and immune-mediated disorders. However, their broad reach also poses safety concerns, which have fuelled a demand for increasingly selective JAK inhibitors.
Tyk2 Targeting in Immune-Mediated Inflammatory Diseases - MDPI
网页2023年1月15日 · Blocking both Tyk2 and Jak1 in this study was more effective than inhibition of Tyk2 alone at reducing psoriasis-like disease severity, keratinocyte proliferation, as well as IL-23, IL-17, IL-6, IL-22, and antimicrobial peptide gene expression, and the authors postulate that targeting a combination of Jak1 and Tyk2 using an orally available ...
TYK2: an emerging therapeutic target in rheumatic disease
网页By participating in signalling pathways downstream of type I interferons, IL-12, IL-23 and IL-10, TYK2 elicits a distinct set of immune events to JAK1, JAK2 and JAK3. TYK2 polymorphisms have been associated with susceptibility to various rheumatic diseases including systemic lupus erythematosus and dermatomyositis.
网页TYK2, a Janus kinase (JAK) family member, plays a significant role in cytokine signaling and immune regulation. This Patent Highlight explores the latest developments in TYK2 inhibitors, highlighting their potential in treating diverse conditions such as cancer, alopecia areata, and psoriatic arthritis.
Review Recent progress on tyrosine kinase 2 JH2 inhibitors
网页2023年8月1日 · Various TYK2-mediated cytokine-stimulated immune cell pathways, including IFN-α-induced STAT1 phosphorylation, IFN-α-stimulated CXCL10 synthesis, IL12-driven IFN-γ production, and IL23-mediated STAT phosphorylation, have been significantly suppressed by JH2 inhibitors. Several TYK2 JH2 inhibitors are currently being studied in …
Tyk2 Targeting in Immune-Mediated Inflammatory Diseases
网页2023年2月8日 · The authors reviewed and summarized the current state of scientific knowledge and understanding of the role of the Tyk2 signaling pathway in immune-mediated inflammatory disease. The manuscript was prepared relatively well, and the descriptions were partly sufficient to support the conclusion.
From Science to Success? Targeting Tyrosine Kinase 2 in ...
网页2021年7月4日 · In this review, we will discuss TYK2 from basic biology to therapeutic targeting, with an emphasis on studies in SpA. Seminal studies uncovering the basic science of TYK2 have provided sound foundations for targeting it …