RAD51 forms a filament on single-stranded DNA ... factors breast and ovarian cancer type 2 susceptibility protein (BRCA2), partner and localizer of BRCA2 (PALB2) and BRCA1-interacting protein ...

These include the ATM and NBS1 proteins that are part of the DSB sensing complex, and the BRCA2 protein that binds to the resected ssDNA (Yang et al., 2002) and catalyzes the formation of the ...

Pharmacogenomics. 2012;13(13):1523-1535. 5-year survival for stage III and IV (%): carriers, 38.1; noncarriers, 24.5 Median survival: p = 0.002 5-year survival for stage III and IV: p < 0.001 [46 ...

(2024) Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin. bioRxiv ... Lim PX, Zaman M, Feng W, Jasin M. (2024) BRCA2 promotes genomic integrity and therapy resistance primarily ...

We identified the breast cancer gene BRCA2, which enabled families with a history of breast cancer to be assessed for future risk, and laid the groundwork for developing novel forms of therapy for ...

Twenty-five years ago today, ICR researchers made the historic discovery of the BRCA2 gene, involved in familial risk of breast, ovarian and prostate cancer. Juanita Bawagan recounts some of their ...

Pharmacogenomics. 2012;13(13):1523-1535. 5-year survival for stage III and IV (%): carriers, 38.1; noncarriers, 24.5 Median survival: p = 0.002 5-year survival for stage III and IV: p < 0.001 [46 ...

Loss of A-type lamins also leads to repression of BRCA1 and RAD51 genes, critical factors in homologous recombination. Interestingly, inhibition of cathepsin L activity with vitamin D or specific ...

The anti-cancer drug olaparib may be effective in treating biochemically recurrent prostate cancer without accompanying hormone therapy for men who have mutations in genes such as BRCA2 ...

For instance, some genes linked to breast cancer, such as BRCA1 and BRCA2, are loading the single-stranded DNA onto RecA (or its human counterpart, RAD51). If these genes are defective ...

When we write a sentence we always use a capital letter at the start and punctuation at the end (usually a full stop). For example: This is an example of how to use capital letters and full stops ...