9月11日，四川大学敖强教授研究团队在期刊《Advanced Science》上发表了题为“A Multi-Functional Nanoadjuvant Coupling Manganese with Toll-Like 9 Agonist ...

近日，约翰·霍普金斯大学医学院的Michael Lim团队在Immunity杂志上发表了文章The cytokine Meteorin-like inhibits anti-tumor CD8 + T cell responses by disrupting mitochondrial ...

该研究揭示，ME2缺失可阻断CD8+T细胞的三羧酸（TCA）循环，导致中间代谢产物富马酸（fumarate）在细胞内堆积。 从治疗干预的角度来说，要想帮CD8 + T ...

One strategy tumors use to ensure survival involves interfering with our inherent immune response.  Effective anti-tumor ...

2024年9月3日，复旦大学生命科学学院/代谢与整合生物学研究院侯宪玉及其合作团队在Advanced Science 在线发表题为“Novel Arf1 ...

proliferate to produce "effector" CD8+ T cells that kill cancer cells. Checkpoint blockade immunotherapies, like anti-PD-1 antibodies, can provide such stimulus. The observation that TCF1 ...

免疫检查点阻断治疗在肝细胞癌 (HCC)患者中的疗效仍然很差。虽然富含丝氨酸和精氨酸的剪接因子 (SRSF)家族成员在肿瘤中起着至关重要的作用，但它们对肿瘤免疫学的影响尚不清楚。

By transforming into more functional exhausted CD8 + T cells, Tpex cells help maintain robust anti-tumor activity. This study ...

T cell immunotherapy can be optimized by understanding the metabolism of T cells. This review article summarizes the intricacies of effector and memory T cell metabolic reprogramming and how ...

Salt could help to boost the immune defense against cancer. This is suggested by the ... sodium has specifically on the activity of human CD8 + T cells," explains Shan Sun, another first author.