CHK2 is a versatile and multifunctional kinase that regulates the cell's response to DNA damage by phosphorylating a number of distinct cellular substrates. CHK2 can prevent tumour progression by ...

英矽智能创始人兼首席执行官Alex Zhavoronkov博士表示：“ ...

The enzyme protein kinase N (PKN) has been implicated in a signaling cascade that causes heart fibroblast activation. A group ...

凭借其在DESTINY-LUNG系列临床试验中展现的卓越疗效，德曲妥珠单抗已成功跻身为全球首个专为治疗HER2突变转移性非小细胞肺癌患者设计的靶向药物，目前也已经得到了美国国立综合癌症网络（NCCN）和中国临床肿瘤学会（CSCO）指南的一致推荐。

Today, thanks in no small part to the advent of kinase inhibitors, the disease is treated by a few pills with minimal side-effects. “Kinase inhibitors have truly revolutionised the way we treat CML,” ...

With over 15 years of experience in kinase drug discovery, DiscoverX offers the largest collection of nearly 500 biochemical and cell-based kinase assays. KINOMEscan® technology, our novel kinase ...

As society ages, the number of patients with heart failure is rapidly increasing. Excessive growth of fibrotic tissue in the ...

心力衰竭（简称心衰）是各种心脏疾病发展的终末阶段，在目前最优化的治疗策略情况下，心衰患者的入院率、死亡率仍然居高不下。RNA结合蛋白是多种心血管疾病的调节因子，RNA解旋酶（dead-box helicase 5，DDX5）是许多RNA的主要调节因子 ...

本次ESMO大会进一步更新报道了中国桥接研究的数据。这项Ⅱ期研究招募了对伊马替尼治疗失败或不耐受的GIST成年患者，随机（1:1）接受瑞派替尼150 mg每日一次（QD）或舒尼替尼50 mg ...

Enliven Therapeutics Inc. has divulged Raf kinase inhibitors reported to be useful for the treatment of cancer. An exemplified compound (Ex 5 [isomer B] pg 130) inhibited ERK phosphorylation in human ...

HOUSTON — Bruton's tyrosine kinase inhibitors such as ibrutinib, acalabrutinib, and zanubrutinib have revolutionized the ...

What sets this supplement apart is its mechanism of action. Berberine activates an enzyme called AMP-activated protein kinase (AMPK), which is central to cellular energy homeostasis. By influencing ...