dendritic cells and T-lymphocytes control the effector immune cells, including, eosinophils, neutrophils, mast cells and basophils to promote inflammation and exacerbation of asthma.

Previous research indicates that mast cells, a type of immune cell found in the tissues throughout the body, cause ...

Macrophages are a major source of TNF-α with significant contributions from other pro-inflammatory cells including monocytes, dendritic cells, B lymphocytes, T cells, neutrophils, mast cells and ...

We aim to demonstrate proof of concept for the depletion of mast cells with briquilimab as an effective mechanism of action in asthma and to inform potential future studies in the broader asthma ...

Mast cells release chemical mediators abundantly ... The most accurate way to diagnose MCAS, according to the American ...

In contrast, increased numbers of mast cells occurred in patients with a moderate to marked decrease in bone density. It is possible that bone-marrow mast cells and heparin, which is synthesized ...

It might be tempting to share your bed with your dog as the weather starts to get colder, but one doctor has said you should ...

The following is a summary of “Clustering of clinical symptoms using large language models reveals low diagnostic specificity of proposed alternatives to consensus mast cell activation syndrome ...

especially from mast cells. Increased risk of asthma-related events (death, hospitalizations, intubations) with LABA monotherapy (without ICS). Do not initiate in rapidly or acutely deteriorating ...

The precise mechanism of corticosteroid action on asthma is not known. However, corticosteroids have been shown to have a wide range of inhibitory effects on multiple cell types (eg, mast cells ...

“Our clinical development plan follows an established and efficient pathway beginning with a challenge study in patients with allergic asthma to enable rapid advancement of the program. We aim to ...