这些新的发现揭示METTL3/METTL14虽然作为经典的mRNA修饰酶，但在维持核仁的相分离和功能方面发挥关键作用。该发现不仅揭示了METTL3/METTL14维持细胞功能的一个从未报道的机制和作用，而且也有助于体现核仁这样一个无膜亚细胞结构如何维 ...

(a) Tumor cells are uniform with round to oval nuclei and inconspicuous nucleoli, arranged in a nested/organoid pattern. Other growth patterns include pseudoglandular, trabecular, and follicular with ...

Superficial urothelial (umbrella) cells have one or multiple nuclei with finely granular chromatin and conspicuous nucleoli, abundant cytoplasm, and low N/C ratios (a and b). For bladder washing ...

8 Tumor of great extension, only focal regression: vacuolization, nuclear piknosis, without nucleoli 6 Tumor of great extension, increased regression in all parts 4 Few tumor nests with marked ...

An evaluation and familiarity with the various nuclear constituents evident in a well-prepared cellular specimen including nuclear envelope (membrane), chromatin, parachromatin distribution and ...

The new study also opens a new front in a different area, aging research. The authors propose a new causal factor in the aging process, which until now would have been overlooked: nucleolar stress, a ...

Primary biliary cirrhosis (PBC) is a chronic, cholestatic liver disease characterized by progressive destruction of intrahepatic bile ducts, resulting in chronic cholestasis, portal inflammation ...