本文来自微信公众号：学术经纬 （ID：Global_Academia），作者：药明康德内容团队，题图来自：AI生成 ...

乙肝表面抗原（hepatitis B surface antigen, HBsAg）自发现以来一直备受关注，但其复杂的结构特性和多样化的组装形态，一直是结构生物学和病毒学长期未解的谜题。

KRAS is the most mutated gene in cancer with mutations occurring in 17%–25% of all cancers, affecting millions of patients ...

乙肝病毒于半个世纪前在澳大利亚被发现。1963年，美国内科与生化学家巴鲁克·塞缪尔·布隆伯格（Baruch Samuel ...

Proteolysis is the enzymatic process by which proteins are degraded into their component polypeptide or amino acid parts. This generally occurs through protease-mediated hydrolysis of peptide ...

清华大学全球健康与传染病研究中心主任张林琦教授说，最近其研究团队从乙肝患者身上分离出了抗乙肝的高强度中和抗体，抗体是保护人体的一种重要免疫机制。有了HBsAg的三维结构，就可以知道这些抗体实际作用在什么地方，找到关键的点位，从而促进疫苗设计的突破。

BioTheryX’s technology platform centers on targeted protein degradation, including PHM ‘molecular glues’, PROteolysis TArgeting Chimeras (PROTACs/PTCs) and monovalent degraders that enable ...

Peroxisome proliferator-activated receptors (PPARs) participate in the fatty acid oxidation, the homeostasis of lipid and glucose metabolism, the regulation of insulin sensitivity, and numerous ...

清华大学全球健康与传染病研究中心主任张林琦教授说，最近其研究团队从乙肝患者身上分离出了抗乙肝的高强度中和抗体，抗体是保护人体的一种重要免疫机制。有了HBsAg的三维结构，就可以知道这些抗体实际作用在什么地方，找到关键的点位，从而促进疫苗设计的突破。

Scientists at Livzon Pharmaceutical Group Inc., Shanghai Institute of Organic Chemistry and the University of Michigan have identified proteolysis targeting chimeras (PROTACs) comprising an E3 ...

The University of Michigan has published details on the discovery and preclinical characterization of a new potent and selective proteolysis targeting chimera (PROTAC) degrader of BRD9, CW-3308.

An assist from a Google Artificial Intelligence tool has helped scientists discover how the proteins of a heat-loving microbe ...