更吸引人的是，根据NCBI的RNA-seq数据，ITIH1是一种仅在肝脏中表达的蛋白质。除了其治疗潜力，它还可能是HCC的诊断生物标志物。未来的研究应探讨ITIH1在HCC中的潜在诊断价值，并建立一个类似于AFP的临界值，以早期诊断HCC。

Research Fellow - joint with Dr. Jenny Nichols at Cambridge University Aragón, E., Wang, Q., Zou, Y., Morgani, S.M.*, Ruiz, L., Kaczmarska, Z., Su, J., Torner, C ...

目前，基于传统的观察性研究，已经确定了特定细胞衰老相关（CSR）基因与多种肿瘤风险之间的关联。例如，EZH2和TOP2A敲低通过诱导细胞衰老，来抑制肝癌发生。IL-1是SASP的关键成分，可促进口腔前体病变的恶性转化。SOX6通过诱导细胞衰老，来抑制 ...

The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.

TβRI then phosphorylates the carboxyl terminus of the transcription factors SMAD2 and SMAD3, enabling them to form a complex with SMAD4. This Smad complex translocates to the nucleus to regulate ...