The leading Toll-Like Receptor 4 (TLR-4) Agonist Companies such as Eisai, Akaza Bioscience, OPNT-003, GeNeuro, MN-166 ...

Activation of macrophage TLR4 by bacterial endotoxins is important for the progression of sepsis, but the underlying ...

2017年10月31日，河南省人民医院心内科在Experimental and therapeutic medicine (中科院四区 IF=2.4)刊上在线发表题为 "Toll-like receptor 2 downregulates the ...

Stewart, C. R. et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nature Immunology 11,155–161 (2010) doi:10.1038/ni.1836. Takeuchi ...

In a recent Perspective in Nature Immunology 1, Blander and Medzhitov explored the function of Toll-like receptor (TLR) signaling in controlling the maturation of phagosomes in macrophages and ...

Toll-like receptors (TLRs) are one of the largest and ... TLRs on the plasma membrane (TLR1, 2, 4 and 6) detect viral proteins, which are released in the extracellular environment, while endosomal ...

Zhijian “James” Chen received this year’s Albert Lasker Award for discovering cGAS, an enzyme which scopes out DNA-based ...

The gastrointestinal microbiome remains an explosively increasing topic of study, assessing the potentially pivotal roles of the microbiome in maintaining health or causality in disease pathogenesis.

Afimetoran is a small molecule commercialized by Bristol-Myers Squibb, with a leading Phase II program in Systemic Lupus Erythematosus.

Innovative use of lipid nanoparticles to deliver immune agonists shows promise in activating anti-tumor immunity in ...

This is especially important if you, like me, operate in all 50 states. Toll-free numbers typically have monthly fees. Weigh this cost against the potential benefits of increased customer calls ...

To address the unmet need for a cure for RTT, the therapeutic potential of adult Neural Precursor Cells (NPCs) was ...