早在20多年前,耶鲁大学的研究人员就在人类机体中发现了一种能抑制 免疫 系统的特殊T细胞类型,后来他们发现,这些所谓的调节性T细胞当发生缺陷时就会诱发一些自身免疫性疾病,尤其是 多发性硬化 症(MS,multiple ...
进一步的机制研究表明,给药的Tregs一旦在受损区域呈现损伤特异性表型。在此过程中,treg显示出与免疫调节和组织愈合相关的基因表达水平增加。进一步的实验表明,Tregs可以导致这些组织中的单核细胞和巨噬细胞切换到抗炎状态,特别是通过分泌白介素-10 (IL-10)等信号分子。
这两项研究论文得出了同样的结论:食盐可以增强杀伤性T细胞的抗肿瘤免疫力。尤其值得一提的是,Enrico Lugli团队还在小鼠身上证实,仅通过高盐饮食就能增强T细胞的抗癌能力,抑制肿瘤的生长。
Rutgers Health researchers will enroll primary or secondary progressive multiple sclerosis (p-MS) patients to see if an ...
Injecting regulatory T cells or Tregs, which control the body’s immune responses, directly into damaged bone, muscle and skin ...
Despite not being everyones favourite vegetable bitter gourd provides various benefits for skin hair and overall health ...
While past research focused on adjusting a patient's immune cells, new studies explore delivering specific cells.
胶质母细胞瘤(GBM)被归类为四级胶质瘤,是中枢神经系统常见的内源性恶性肿瘤。尽管实施了包括较大限度手术切除、放疗和以替莫唑胺(TMZ)为基础的化疗联合后续序贯TMZ治疗的标准治疗方案,但新诊断的GBM患者的平均总生存(OS)时间仅为14.6个月。胶质母细胞瘤干细胞(GSCs)是一小部分具有自我更新和多向分化能力的GBM细胞,被认为是GBM肿瘤发生和发展的责任方。GSCs还具有辐射抵抗、化疗抵抗、 ...
根据中国药物临床试验登记与信息公示平台,安进已经在中国启动AMG 451的多项临床研究,适应症包括特应性皮炎和哮喘。此次AMG 451再次获批临床,意味着该产品即将在新的结节性痒疹疾病领域进行临床探索。
A team of scientists from the Perelman School of Medicine at the University of Pennsylvania and Aum Biotech LLC have described the development of a novel cancer immunotherapy designed to target ...
China’s National Intellectual Property Administration has issued notification to grant patent to PolTREG Chinese patent covers intrathecal ...