Bile acids are essential signaling molecules derived from cholesterol metabolism in the liver and are crucial for the ...

Cancer cells frequently develop mechanisms to evade apoptosis, increasing resistance to standard chemotherapy treatments. This resistance has prompted extensive research into alternative mechanisms of ...

本文已于2024年9月2日被撤回： 本文发表后，一位热心的读者向编辑指出，第3763页图1D中显示的某些细胞凋亡测定数据，与另一篇由不同研究机构的不同作者以不同形式提交发表的文章（图3A）中的数据惊人地相似。鉴于上述有争议的数据在提交给《 ...

InnoCare Pharma gets Chinese nod to begin clinical trial of BCL2 inhibitor ICP-248 for acute myeloid leukaemia: Beijing Friday, September 20, 2024, 18:00 Hrs [IST] InnoCare Pharma ...

Additionally, p53 pathway restoration in p53-deficient cancers can be achieved by small molecules ... cell-type-dependent manner. They also note that PUMA mediates apoptosis through the activation of ...

Recent research addresses this gap by demonstrating that caspase-2 directly processes BID, initiating the mitochondrial pathway of apoptosis. Moreover, the team discovered HUHS015, a compound that ...

“I anticipated that our knowledge of this pathway and my clinical training in haematology and oncology would place us in an ideal position to evaluate molecules that trigger apoptosis ...

本文发表后，一位热心的读者向编辑指出，第3763页图1D中显示的某些细胞凋亡测定数据，与另一篇由不同研究机构的不同作者以不同形式提交发表的文章（图3A）中的数据惊人地相似。鉴于上述有争议的数据在提交给《 Molecular Medicine ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...