dendritic cells and T-lymphocytes control the effector immune cells, including, eosinophils, neutrophils, mast cells and basophils to promote inflammation and exacerbation of asthma.

However, they are also involved in inflammatory and fibrotic processes. Mast cells participate in all the stages of acute inflammatory responses, playing an immunomodulatory role in both innate and ...

We aim to demonstrate proof of concept for the depletion of mast cells with briquilimab as an effective mechanism of action in asthma and to inform potential future studies in the broader asthma ...

(Nasdaq: JSPR) (Jasper), a clinical stage biotechnology company focused on development of briquilimab, a novel antibody therapy targeting c-Kit (CD117) to address mast cell driven diseases such as ...

Due to the chronic nature of human asthma and challenges in modeling it accurately, researchers primarily rely on mouse models to investigate the role of IL-33 in activating ILC2s and driving type 2 ...

Allergen immunotherapy (also known as allergy shots) is a form of long-term treatment for people with seasonal asthma, hay fever (allergic rhinitis), and conjunctivitis (eye allergy). Allergy shots ...

Route E-64, University of Texas Medical Branch, Galveston, Texas, USA. Background—Mast cells have been shown to regulate intestinal ion transport in animal models and normal human colon but their ...

In contrast, increased numbers of mast cells occurred in patients with a moderate to marked decrease in bone density. It is possible that bone-marrow mast cells and heparin, which is synthesized ...

Macrophages are a major source of TNF-α with significant contributions from other pro-inflammatory cells including monocytes, dendritic cells, B lymphocytes, T cells, neutrophils, mast cells and ...