This study investigates the critical role of epigenetic PPARγ (peroxisome proliferator–activated receptor-gamma) suppression in OA development. Methods Articular cartilage expressions of PPARγ and ...

This study demonstrated that EPO enhanced osteoclast differentiation and bone resorption in vitro. We showed that EPO promoted osteoclast formation by up-regulating PPARγ expression through activating ...

This study provides useful data substantiating a role of long noncoding RNAs in liver metabolism and organismal physiology. With murine knockout and knockin models, the authors invoke a previously ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

The following were measured using enzyme linked immunosorbent assay (ELISA)kits: Human ADIPONECTIN kit EZHADP-61K Human Leptin kit ... Thus, adipogenic gene machinery of PPARγ, and ADIPISIN are ...

The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent breakthroughs have arisen ...

Adaptive thermogenesis, defined as the heat produced in response to environmental temperature or diet, can be divided into three subtypes. Cold exposure induces shivering thermogenesis, a function ...

Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) marked by persistent inflammation of the mucosal lining of the large intestine, leading to debilitating symptoms and reduced ...

Objective Endocrine-disrupting chemicals (EDCs) are viewed as a major potential link between the environment and obesity development. We did a systematic review and meta-analysis to examine the ...