In bone marrow, mastocytosis mast cells may have cytoplasmic extensions such as spindles or fusiform shapes, oval nuclei with excentric positioning, and/or hypogranulated cytoplasm with focal ...

The past decade has seen significant advances in our understanding of skeletal homeostasis and the mechanisms that mediate the loss of bone integrity in disease. Recent breakthroughs have arisen ...

Chemotherapy (aggressive systemic mastocytosis). Local radiation for bone pain. Low-dose aspirin is helpful in some patients, because it causes continuous degranulation and prevents extreme peaks ...

Mastocytosis can be difficult to diagnose and it can a very frustrating process. Correctly identifying the clinical symptoms aids in the diagnosis. Sometimes skin lesions and bone marrow are biopsied ...

The case of a 70-year-old woman with systemic mastocytosis (SM) who demonstrated cutaneous, bone marrow, and gastrointestinal involvement was presented at the 12th annual meeting of the Society of ...

Cogent Biosciences' uncertain competitive edge may compel investors to sit on the sidelines. Read more about the cautious ...

Skeletal system photos and labeled diagrams can help you to understand the parts of the skeleton, how it's organized, the conditions that can affect it, and tests used to diagnose skeletal health. The ...

This procedure was performed without complications. Histology demonstrated the presence of small-to-intermediate cell aggregates; immunohistochemistry showed positivity for CD117 and CD25, suggestive ...

Sudipto Mukherjee, MD, PhD, MPH, of Cleveland Clinic, describes the steps clinicians should take when they encounter clinical abnormalities that may point to systemic mastocytosis. (1:48 ...

Of 135 women beyond fifty years of age who were evaluated for levels of bone density, those with a normal or only a minimally decreased bone density had the highest number of normal bone-marrow ...

The following is a summary of “Comparison of prognostic scores according to WHO classification in 170 patients with advanced mastocytosis and C-finding treated with midostaurin,” published in the ...

Bone marrow is a soft, spongy material inside your bones where blood cells are made. These blood cells are important for a healthy immune system. (Photo Credit: Wendy Hiller Gee/Eric Olson/WebMD ...