2024 年 ESMO 年会将于当地时间 9 月 13 日至 17 日在西班牙巴塞罗那召开。本次大会上，赛诺菲首次公布了其 CD3 X CD28 X HER2 三抗 SAR443216 治疗晚期实体瘤的 1 期临床数据。 Insight 数据库显示，SAR443216 曾是全球首个进入临床阶段的 CD3 X CD28 X HER2 三抗。在 2023年 Q4 财报 ...

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1). Although attention has historically focused on Grb2-mediated recruitment to receptor tyrosine kinases as a means of localizing SOS to the plasma membrane, recent work has revealed increasing ...

T cell activation requires engagement of a cognate antigen by the T cell receptor (TCR) and the co-stimulatory signal of CD28. Both TCR and CD28 aggregate into clusters at the plasma membrane of ...

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On the same day, TikToker [5] @realace5star posted a version of the meme that gained over 141,000 views in two weeks (shown below, left). On July 18th, TikToker [6] @sparklesandchampagne1738 posted a ...

Holiday shopping season is nearly here, and the reality is that most online shopping carts become abandoned. Even though more people will be shopping in the coming months leading up to the ...

Walmart is rolling out new shopping carts to help parents who have children with disabilities. The carts, which have a large seat on the back that can carry someone weighing up to 250 pounds ...

BACKGROUND Lack of CD28 expression on peripheral blood CD4+ and CD8+ T cells has been reported in patients with Wegener's granulomatosis (WG), suggesting a pathogenetic role of CD28– T cells in WG.