9月11日，四川大学敖强教授研究团队在期刊《Advanced Science》上发表了题为“A Multi-Functional Nanoadjuvant Coupling Manganese with Toll-Like 9 Agonist ...

近日，约翰·霍普金斯大学医学院的Michael Lim团队在Immunity杂志上发表了文章The cytokine Meteorin-like inhibits anti-tumor CD8 + T cell responses by disrupting mitochondrial ...

该研究揭示，ME2缺失可阻断CD8+T细胞的三羧酸（TCA）循环，导致中间代谢产物富马酸（fumarate）在细胞内堆积。 从治疗干预的角度来说，要想帮CD8 + T ...

One strategy tumors use to ensure survival involves interfering with our inherent immune response.  Effective anti-tumor ...

2024年9月3日，复旦大学生命科学学院/代谢与整合生物学研究院侯宪玉及其合作团队在Advanced Science 在线发表题为“Novel Arf1 ...

proliferate to produce "effector" CD8+ T cells that kill cancer cells. Checkpoint blockade immunotherapies, like anti-PD-1 antibodies, can provide such stimulus. The observation that TCF1 ...

免疫检查点阻断治疗在肝细胞癌 (HCC)患者中的疗效仍然很差。虽然富含丝氨酸和精氨酸的剪接因子 (SRSF)家族成员在肿瘤中起着至关重要的作用，但它们对肿瘤免疫学的影响尚不清楚。

Although MDS cells were originally observed in cancer patients and experimental animals >30 years ago, their role as spoilers of anti-tumor immunity ... of CD4 + and CD8 + T lymphocytes ...

By transforming into more functional exhausted CD8 + T cells, Tpex cells help maintain robust anti-tumor activity. This study ...

Salt could help to boost the immune defense against cancer. This is suggested by the ... sodium has specifically on the activity of human CD8 + T cells," explains Shan Sun, another first author.