In June 2024, the US Food and Drug Administration (FDA) approved Vyvgart ® Hytrulo (efgartigimod alfa and hyaluronidase-qvfc; Argenx BV) for the treatment of adults with chronic inflammatory ...

This study is the first to explore exosomal mRNA profiles in MPO-AAV, offering insights into the molecular underpinnings of this disease. A recent study published in Clinical and Experimental Medicine ...

A statistical analysis by the author revealed that only two alleles, namely DRB1*04:04 and DRB1*03, had a direct correlation with MG prevalence. Two human leukocyte antigens (HLA) class 2 alleles ...

A 10-minute injection or a 2-hour infusion? Which way would you prefer to treat your multiple sclerosis (MS)? That choice is about to be available, following the US Food and Drug Administration’s ...

Frail patients were more likely to receive less rituximab and more glucocorticoids, with many receiving no treatment, particularly among those aged 75 years and older. Frailty, a measure of biological ...

To further clarify and define the role of specific T-cell subtypes and their signaling cascades in patients with AAV-associated GN, the investigators generated a single-cell transcriptome and epitope ...

Which of the statements below about the risk factors for hemolytic disease of the fetus and newborn (HDFN) are correct? Select one of the options for each question, then submit your answers to see how ...

Mahesh Desai, PhD, discusses how healthy gut bacteria may reduce the side effects of chemotherapy in cancer patients. Larry Luxner, senior correspondent for Rare Disease Advisor, interviews Mahesh ...

Intravenous immunoglobulin therapy was associated with a later gestational age at birth and improved chances of survival. A new systematic review and analysis has determined that maternal intravenous ...

The weak D phenotype results in the weak expression of D antigens on red blood cells, minimizing the risk of HDFN. In the Indonesian Journal of Obstetrics & Gynecology Science, physicians presented ...

Both patients showed a significant and stable improvement of hearing threshold and speech perception following cochlear implant. Hereditary transthyretin-related amyloidosis with polyneuropathy ...

The current study demonstrated the use of PBPK modeling to potentially avoid the need of additional clinical studies to address the DDI gaps. Physiologically-based pharmacokinetic (PBPK) modeling and ...