The role of human mast cells in allergy and asthma - PMC
网页2022年3月10日 · In asthma and allergic diseases, mast cells are stimulated by the allergen-IgE complex to release a variety of de novo synthesized and granularly stored mediators. These mediators released by mast cells are the main drivers of inflammation, as they include cytokines, lipid mediators, and proteases …
The role of the mast cell in the pathophysiology of asthma
网页There is compelling evidence that human mast cells contribute to the pathophysiology of asthma. Mast cells, but not T cells or eosinophils, localize within the bronchial smooth muscle bundles in patients with asthma but not in normal subjects or those with eosinophilic bronchitis, a factor likely to ….
Human Lung Mast Cells: Therapeutic Implications in Asthma
网页2022年11月21日 · Mast cells are strategically located in different compartments of the lung in asthmatic patients. These cells are widely recognized as central effectors and immunomodulators in different asthma phenotypes. Mast cell mediators activate a wide spectrum of cells of the innate and adaptive immune system during airway inflammation.
Mast Cells and Their Progenitors in Allergic Asthma
网页2019年5月29日 · Mast cells are key players in the asthmatic response through secretion of a multitude of mediators with pro-inflammatory and airway-constrictive effects. Well-known mast cell mediators, such as histamine and bioactive lipids are responsible for many of the physiological effects observed in the acute phase of allergic reactions.
Mast cells in asthma--state of the art - PubMed
网页Mast cells (MCs) play a central role in tissue homoeostasis, sensing the local environment through numerous innate cell surface receptors. This enables them to respond rapidly to perceived tissue insults with a view to initiating a co …
Understanding human mast cells: lesson from therapies for
网页2021年10月5日 · In patients with asthma, mast cells infiltrating the smooth muscle layer displayed signs of activation and degranulation when imaged by electron microscopy 58.
The role of human mast cells in allergy and asthma - PubMed
网页FcεRI-activated mast cells are known to release histamine and proteases that contribute to asthma symptoms. They release a variety of cytokines and lipid mediators that contribute to immune cell accumulation and tissue remodeling in asthma. Mast cell mediators trigger inflammation and also have a protective effect.
Role of mast cells in allergic and non-allergic immune ... - Nature
网页Mast-cell mediators affect the mucosa, the blood vessels and sensory nerves at sites of allergy; mast-cell proteases and cytokines contribute to the initiation of a facultative late-phase...
Mast cells in asthma: Here I am, stuck in the middle with you
网页Mast cells play an important role in allergic lung inflammation in asthma, contributing to both the early-phase reaction as well as the late-phase reactions of asthma through the release of numerous agents [1]. Mast cell precursors from the blood migrate to and embed themselves into the airway wall, including within airway smooth muscle (ASM ...
Mechanisms of Mast Cell Activation in Severe Asthma: Beyond IgE ...
网页In summary, Tiotiu and colleagues provide insight into some IgE-independent pathways that are active in the airways of people with severe asthma. These data should be considered the tip of the iceberg in unraveling the multiple factors that …