Formal Synthesis of the ACE Inhibitor Benazepril·HCl via an …
网页2006年8月23日 · This report has offered a novel strategy for the asymmetric synthesis of the ACE inhibitor benazepril·HCl (4). Through an asymmetric aza-Michael reaction, we kinetically synthesized (2S,3’S)-2-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester (8), a known key intermediate for the preparation of compound 4
Benazepril Hydrochloride: Comprehensive Profile - ScienceDirect
网页2005年1月1日 · Benazepril hydrochloride, an angiotensin-converting enzyme (ACE) inhibitor, is used in the treatment of hypertension and heart failure. Benazepril hydrochloride, being a prodrug of the diacid benazeprilat, is rapidly absorbed and converted to the active ACE inhibitor, benazeprilat.
网页A benazepril intermediate was synthesized through asymmetric synthesis using aromatic aminotransferase from obactenteErr sp . BK2K-1 (AroAT Es ). Sodium 4-methoxy-4-(2-nitrophen- yl)-2-oxobutanoate ( 1 ) and ( E )-4-(2-nirot pheny)-2l -oxobut- 3-enoic acid ( 2 ) were tested as amino acceptors for the transamination by AroAT Es .
CN110835319A - Synthesis method of benazepril intermediate …
网页The invention provides a synthesis method of a benazepril intermediate, which takes a compound 18 as a precursor to react with a compound 6, and obtains a compound 19 through a dynamic kinetic...
Use of convertible isocyanides for the synthesis of benazepril ...
网页2021年4月7日 · Herein, we have described a novel and concise synthesis of the potent angiotensin-converting enzyme (ACE) inhibitor, benazepril hydrochloride (7) in trifluoroethanol via an Ugi three-component reaction in shorter reaction times. The key step is the trifluoroacetic acid-mediated hydrolysis of secondary amides (4a and 4b) followed by ...
Asymmetric synthesis of ACE inhibitor-Benazepril HCl via a bioreductive ...
网页2003年8月1日 · An enantioselective synthesis of the potent angiotensin converting enzyme (ACE) inhibitor (2S, 3′S)-2-(1-carboxymethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-ylamino)-4-phenylbutyric acid ethyl ester hydrochloride, Benazepril HCl 4, has been achieved through an asymmetric reduction of 4-(2-nitrophenyl)-2,4 …
Benazepril Hydrochloride: Comprehensive Profile - ScienceDirect
网页2005年1月1日 · Benazepril hydrochloride, being a prodrug of the diacid benazeprilat, is rapidly absorbed and converted to the active ACE inhibitor, benazeprilat. The chapter discusses the method of preparation for benazepril hydrochloride.
Formal synthesis of the ACE inhibitor benazepril x HCl via an ...
网页2006年8月23日 · A formal enantioselective synthesis of benazepril.HCl (4), an anti- hypertensive drug, is reported. Our synthesis employed an asymmetric aza-Michael addition of L-homophenylalanine ethyl ester (LHPE, 1) to 4- (2-nitrophenyl)-4-oxo- but-2-enoic acid methyl ester (6) as the key step to prepare (2S,3'S) ….
Aminotransferase-catalyzed asymmetric synthesis of benazepril ...
网页2011年10月5日 · A benazepril intermediate was synthesized through asymmetric synthesis using aromatic aminotransferase from Enterobacter sp. BK2K-1 (AroATEs). Sodium 4-methoxy-4-(2-nitrophenyl)-2-oxobutanoate (1) and (E)-4-(2-nitrophenyl)-2-oxobut-3-enoic acid (2) were tested as amino acceptors for the transamination by AroATEs.
Aminotransferase-catalyzed Asymmetric Synthesis of Benazepril ...
网页2011年8月1日 · A benazepril intermediate was synthesized through asymmetric synthesis using aromatic aminotransferase from Enterobacter sp. BK2K-1 (AroATEs). Sodium 4-methoxy-4- (2-nitrophenyl)-2-oxobutanoate...
跳至内容