The short-term effects of berberine in the liver: Narrow margins ...
网页2022年9月1日 — Berberine is a plant alkaloid to which antihyperglycemic properties have been attributed. It is also known as an inhibitor of mitochondrial functions. In this work short-term translation of the latter effects on hepatic metabolism were investigated using the isolated perfused rat liver. Once-through ….
Update on Berberine in Nonalcoholic Fatty Liver Disease
网页2013年6月17日 — Berberine (BBR), an active ingredient from nature plants, has demonstrated multiple biological activities and pharmacological effects in a series of metabolic diseases including nonalcoholic fatty liver disease (NAFLD). The recent literature points out that BBR may be a potential drug for NAFLD in …
The clinical efficacy and safety of berberine in the treatment of …
网页2024年3月1日 — Importantly, Berberine exhibited a favorable safety profile, with only mild gastrointestinal adverse events reported. This meta-analysis demonstrates berberine's efficacy in improving liver enzymes, lipid profile, and insulin sensitivity in NAFLD patients. These results indicate that berberine shows promise as an adjunct therapy for NAFLD.
Berberine in Non-Alcoholic Fatty Liver Disease—A Review
网页2022年8月23日 — BBR can penetrate the blood-brain barrier, and its metabolites are widely distributed in the liver, muscle, kidney, lung, heart, brain, pancreas, and adipose tissue. The organ distribution of BBR is fast, with maximum allocation in the liver and a minor distribution in fat [36].
Berberine - LiverTox - NCBI Bookshelf - National Center for ...
网页2020年10月6日 — Despite wide scale use as an herbal supplement, berberine has not been linked to published instances of clinically apparent liver injury. The frequency of hypersensitivity reactions to berberine is also not known. Likelihood score: E (unlikely cause of clinically apparent liver injury). Other Names: Goldenseal, Oregon grape, Tree turmeric.
Molecular updates on berberine in liver diseases: Bench to bedside
网页BBR has been shown to modulate multiple signaling pathways implicated in the pathogenesis of liver diseases including Akt/FoxO2, PPAR-γ, Nrf2, insulin, AMPK, mTOR, and epigenetic pathways. In the present review, we have emphasized the important pharmacological activities and mechanisms of BBR in liver diseases.
The short-term effects of berberine in the liver: Narrow margins ...
网页2022年9月1日 — Berberine decreases gluconeogenesis and increases glycolysis in the perfused liver. • Berberine impairs hepatic ammonia detoxification. • Berberine diminishes liver ATP content and increases NADH/NAD+ ratio. • Effects are a consequence of impairment on mitochondrial respiration and pyruvate carboxylation. •
Berberine in Non-Alcoholic Fatty Liver Disease-A Review
网页2022年8月23日 — One of the most promising is Berberine (BBR). Its pleiotropic effect positively impacts various cardiometabolic aspects. In this review, we summarize NAFLD, its metabolic and cardiovascular complications, the hepatoprotective effects of BBR due to its broad spectrum of pharmacological effects, and the potential role of BBR in NAFLD therapy.
Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver
网页2015年8月7日 — A total of 184 eligible patients with NAFLD were enrolled and randomly received (i) lifestyle intervention (LSI), (ii) LSI plus pioglitazone (PGZ) 15mg qd, and (iii) LSI plus BBR 0.5g tid, respectively, for 16 weeks.
A phase 2, proof of concept, randomised controlled trial of berberine …
网页2021年9月17日 — Thus, subjects receiving 1000 mg twice a day of berberine ursodeoxycholate had significantly greater reduction in liver fat content than in placebo recipients (mean absolute decrease −4.8% vs....
- 某些结果已被删除