Efficacy of berberine in treatment of rheumatoid arthritis: From ...
网页Rheumatoid arthritis is a systemic autoimmune disorder involved in persistent synovial inflammation. Berberine is a nature-derived alkaloid compound with multiple pharmacological activities in different pathologies, including RA. Recent experimental studies have clarified several determinant cellula …
Immunomodulatory effects of berberine on the inflamed joint …
网页2020年9月23日 · Berberine can suppress synovial joint inflammation together with cartilage and bone damage through inhibiting inflammatory proliferation of FLS cells, suppressing DC activation, modulating Th17/Treg balance, as well as inducing the gut‐mediated immunosuppression and adjusting the gut microbiota.
Anti‐inflammatory and immune‐modulatory impacts of berberine …
网页2020年11月1日 · Reported data reveal that berberine can directly suppress functions and differentiation of pro‐inflammatory Th1 and Th17 cells, and indirectly decrease Th cell‐mediated inflammation through modulating or suppressing other cells assisting autoreactive inflammation, such as Tregs, DCs and macrophages.
Efficacy of berberine in treatment of rheumatoid arthritis: From ...
网页2021年7月1日 · Berberine attenuates arthritis in adjuvant-induced arthritic rats associated with regulating polarization of macrophages through AMPK/NF-кB pathway Eur. J. Pharmacol. , 852 ( 2019 ) , pp. 179 - 188
Berberine and musculoskeletal disorders: The therapeutic potential …
网页2020年7月15日 · Results: Berberine may potentially retard the progression of osteoporosis, osteoarthritis and rheumatoid arthritis. Limited studies reported the effects of berberine in suppressing the proliferation of osteosarcoma cells.
Berberine Delays Onset of Collagen-Induced Arthritis through T …
网页2021年3月29日 · There is evidence that berberine (BBR), a clinically relevant plant compound, ameliorates clinically apparent collagen-induced arthritis (CIA) in vivo. However, to date, there are no studies involving the use of BBR which explore its prophylactic potential in this model of rheumatoid arthritis (RA). ….
Berberine, a natural alkaloid: Advances in its pharmacological …
网页2024年8月20日 · In rheumatoid arthritis, berberine's effects on fibroblast-like synovial cells, dendritic cells, and CD4 + T cells are discussed, highlighting its potential to mitigate synovial inflammation and prevent cartilage and bone damage.
Efficacy of berberine in treatment of rheumatoid arthritis: From ...
网页2021年7月1日 · In this review, we recapitulate the therapeutic potential of BBR and its mechanism of action in ameliorating RA, and discuss the modulation of gut microbiota by BBR during RA. Collectively, BBR might be a promising lead drug with multi-functional activities for the therapeutic strategy of RA.
Berberine inhibits RA-FLS cell proliferation and ... - BONE AND …
网页This study is the first to demonstrate the anti-rheumatoid effect of berberine in rheumatoid arthritis fibroblast-like synoviocyte (RA-FLS) cells, and explore the potential mechanism through the biochemical index evaluation, transcriptomics, and molecular biotechnology.
Berberine: Health Benefits, Side Effects, Risks, and More
网页2023年6月2日 · “Berberine is a type of chemical compound called an alkaloid that is found in the roots, leaves, stems, and barks of plants, such as barberry, Oregon grape, and tree turmeric,” says Vicki Shanta...
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